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Non-Affective Psychotic Disorders

Kathryn M Abel, Holly Hope, Eleanor Swift, Rosa Parisi, Darren M Ashcroft, Kyriaki Kosidov, Semre Su Osam, Christian Dolman, Mathias Pierce

Type
Disease or Syndrome
ID
PH825
Version ID
1729
Data Sources
Valid event data range
01/01/2005 - 31/12/2017
Sex
Female
Agreement Date
2019-06-30
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Background:

Little information exists about the prevalence of children exposed to maternal mental illness. We aimed to estimate the prevalence of children and adolescents exposed to maternal mental illness in the UK between 2005 and 2017 using primary care data.

Methods:

In this national retrospective cohort study, we included children aged 0–16 years born between Jan 1, 1991, and Dec 31, 2015, who were linked to their mothers and registered on the primary care Clinical Practice Research Datalink (CPRD) between 2005 and 2017. We extracted data on diagnosis, symptoms, and therapy from the CRPD to define the following maternal mental illnesses: depression, anxiety, non-affective psychosis, affective psychosis, eating disorders, personality disorders, alcohol misuse disorder, and substance misuse disorder. We also extracted data on socioeconomic status from the Index of Multiple Deprivation 2010 and data on ethnicity from the Hospital Episode Statistics dataset. The main outcome was prevalence of maternal mental illness. Prevalence was calculated for each 2-year period of childhood (from age 0–<2 to 14–<16 years) using marginal predictions from a logistic regression model. We used survival analysis to estimate the incidence and cumulative risk of children experiencing maternal mental illness by age 16 years.

Findings:

We identified 783 710 children registered in the UK CPRD mother-baby link database, and included 547 747 children (381 685 mothers) in our analysis. Overall prevalence of maternal mental illness was 23·2% (95% CI 23·1–23·4), which increased during childhood (21·9%, 21·7–22·1 among the 0–<2 year age group vs 27·3%, 26·8–27·8 among the 14–<16 year age group). Depression and anxiety were the most prevalent maternal mental illnesses. The proportion of children exposed to maternal mental illness increased from 22·2% (21·9–22·4) between 2005 and 2007 to 25·1% (24·8–25·5) between 2015 and 2017. Geographically, the highest prevalence of maternal mental illness was observed in Northern Ireland (29·8%, 29·0–30·5). In England, prevalence of maternal mental illness was highest among children in the most deprived areas (28·3%, 27·8–28·8). The incidence of maternal mental illness was highest between 0–3 months (26·7 per 100 person years, 26·4–27·1). By age 16 years, the cumulative risk of maternal mental illness was 53·1% (52·8–53·3).

Interpretation:

One in four children aged 0–16 years are exposed to maternal mental illness and the prevalence of diagnosed and treated maternal mental illness is increasing. Policy makers and commissioners should consider this information and channel resources to target individuals in greatest need.

Publications

  • Kathryn M Abel, Holly Hope, Eleanor Swift, Rosa Parisi, Darren M Ashcroft, Kyriaki Kosidov, Samre Su Osam, Christian Dolman, Mathias Pierce, Prevalence of maternal mental illness among children and adolescents in the UK between 2005 and 2017: a national retrospective cohort analysis. Lancet Public Health, 4, e291–300, 2019.

Clinical Code List

Rows: 162
Code Description Entity type Category Coding System (Read)
1464.00 H/O: schizophrenia res76: Non-affective psychotic disorders diagnostic Read
146H.00 H/O: psychosis res76: Non-affective psychotic disorders diagnostic Read
1B1E.00 Hallucinations res76: Non-affective psychotic disorders symptom Read
1BH..00 Delusions res76: Non-affective psychotic disorders diagnostic Read
1BH..11 Delusion res76: Non-affective psychotic disorders diagnostic Read
1BH0.00 Delusion of persecution res76: Non-affective psychotic disorders diagnostic Read
1BH1.00 Grandiose delusions res76: Non-affective psychotic disorders symptom Read
1BH2.00 Ideas of reference res76: Non-affective psychotic disorders symptom Read
1BH3.00 Paranoid ideation res76: Non-affective psychotic disorders symptom Read
212W.00 Schizophrenia resolved res76: Non-affective psychotic disorders diagnostic Read
212X.00 Psychosis resolved res76: Non-affective psychotic disorders diagnostic Read
225E.00 O/E - paranoid delusions res76: Non-affective psychotic disorders diagnostic Read
225F.00 O/E - delusion of persecution res76: Non-affective psychotic disorders diagnostic Read
285..11 Psychotic condition, insight present res76: Non-affective psychotic disorders diagnostic Read
286..11 Poor insight into psychotic condition res76: Non-affective psychotic disorders diagnostic Read
8HHs.00 Referral to psychosis early intervention service res76: Non-affective psychotic disorders diagnostic Read
E1...00 Non-organic psychoses res76: Non-affective psychotic disorders diagnostic Read
E10..00 Schizophrenic disorders res76: Non-affective psychotic disorders diagnostic Read
E100.00 Simple schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E100.11 Schizophrenia simplex res76: Non-affective psychotic disorders diagnostic Read
E100000 Unspecified schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E100100 Subchronic schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E100200 Chronic schizophrenic res76: Non-affective psychotic disorders diagnostic Read
E100300 Acute exacerbation of subchronic schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E100400 Acute exacerbation of chronic schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E100500 Schizophrenia in remission res76: Non-affective psychotic disorders diagnostic Read
E100z00 Simple schizophrenia NOS res76: Non-affective psychotic disorders diagnostic Read
E101.00 Hebephrenic schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E101000 Unspecified hebephrenic schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E101400 Acute exacerbation of chronic hebephrenic schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E101500 Hebephrenic schizophrenia in remission res76: Non-affective psychotic disorders diagnostic Read
E101z00 Hebephrenic schizophrenia NOS res76: Non-affective psychotic disorders diagnostic Read
E102.00 Catatonic schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E102000 Unspecified catatonic schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E102100 Subchronic catatonic schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E102400 Acute exacerbation of chronic catatonic schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E102500 Catatonic schizophrenia in remission res76: Non-affective psychotic disorders diagnostic Read
E102z00 Catatonic schizophrenia NOS res76: Non-affective psychotic disorders diagnostic Read
E103.00 Paranoid schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E103000 Unspecified paranoid schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E103100 Subchronic paranoid schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E103200 Chronic paranoid schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E103300 Acute exacerbation of subchronic paranoid schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E103400 Acute exacerbation of chronic paranoid schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E103500 Paranoid schizophrenia in remission res76: Non-affective psychotic disorders diagnostic Read
E103z00 Paranoid schizophrenia NOS res76: Non-affective psychotic disorders diagnostic Read
E104.00 Acute schizophrenic episode res76: Non-affective psychotic disorders diagnostic Read
E104.11 Oneirophrenia res76: Non-affective psychotic disorders diagnostic Read
E105.00 Latent schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E105000 Unspecified latent schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E105200 Chronic latent schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E105500 Latent schizophrenia in remission res76: Non-affective psychotic disorders diagnostic Read
E105z00 Latent schizophrenia NOS res76: Non-affective psychotic disorders diagnostic Read
E106.00 Residual schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E10y.00 Other schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E10y.11 Cenesthopathic schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E10y000 Atypical schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E10y100 Coenesthopathic schizophrenia res76: Non-affective psychotic disorders diagnostic Read
E10yz00 Other schizophrenia NOS res76: Non-affective psychotic disorders diagnostic Read
E10z.00 Schizophrenia NOS res76: Non-affective psychotic disorders diagnostic Read
E12..00 Paranoid states res76: Non-affective psychotic disorders diagnostic Read
E120.00 Simple paranoid state res76: Non-affective psychotic disorders diagnostic Read
E121.00 Chronic paranoid psychosis res76: Non-affective psychotic disorders diagnostic Read
E122.00 Paraphrenia res76: Non-affective psychotic disorders diagnostic Read
E123.00 Shared paranoid disorder res76: Non-affective psychotic disorders diagnostic Read
E123.11 Folie a deux res76: Non-affective psychotic disorders diagnostic Read
E12y.00 Other paranoid states res76: Non-affective psychotic disorders diagnostic Read
E12y000 Paranoia querulans res76: Non-affective psychotic disorders diagnostic Read
E12yz00 Other paranoid states NOS res76: Non-affective psychotic disorders diagnostic Read
E12z.00 Paranoid psychosis NOS res76: Non-affective psychotic disorders diagnostic Read
E13..00 Other nonorganic psychoses res76: Non-affective psychotic disorders diagnostic Read
E13..11 Reactive psychoses res76: Non-affective psychotic disorders diagnostic Read
E130.11 Psychotic reactive depression res76: Non-affective psychotic disorders diagnostic Read
E132.00 Reactive confusion res76: Non-affective psychotic disorders diagnostic Read
E133.00 Acute paranoid reaction res76: Non-affective psychotic disorders diagnostic Read
E133.11 Bouffee delirante res76: Non-affective psychotic disorders diagnostic Read
E134.00 Psychogenic paranoid psychosis res76: Non-affective psychotic disorders diagnostic Read
E13y.00 Other reactive psychoses res76: Non-affective psychotic disorders diagnostic Read
E13y100 Brief reactive psychosis res76: Non-affective psychotic disorders diagnostic Read
E13yz00 Other reactive psychoses NOS res76: Non-affective psychotic disorders diagnostic Read
E13z.00 Nonorganic psychosis NOS res76: Non-affective psychotic disorders diagnostic Read
E13z.11 Psychotic episode NOS res76: Non-affective psychotic disorders diagnostic Read
E1y..00 Other specified non-organic psychoses res76: Non-affective psychotic disorders diagnostic Read
E1z..00 Non-organic psychosis NOS res76: Non-affective psychotic disorders diagnostic Read
Eu0z.12 [X]Symptomatic psychosis NOS res76: Non-affective psychotic disorders symptom Read
Eu2..00 [X]Schizophrenia, schizotypal and delusional disorders res76: Non-affective psychotic disorders diagnostic Read
Eu20.00 [X]Schizophrenia res76: Non-affective psychotic disorders diagnostic Read
Eu20000 [X]Paranoid schizophrenia res76: Non-affective psychotic disorders diagnostic Read
Eu20011 [X]Paraphrenic schizophrenia res76: Non-affective psychotic disorders diagnostic Read
Eu20100 [X]Hebephrenic schizophrenia res76: Non-affective psychotic disorders diagnostic Read
Eu20111 [X]Disorganised schizophrenia res76: Non-affective psychotic disorders diagnostic Read
Eu20200 [X]Catatonic schizophrenia res76: Non-affective psychotic disorders diagnostic Read
Eu20211 [X]Catatonic stupor res76: Non-affective psychotic disorders diagnostic Read
Eu20212 [X]Schizophrenic catalepsy res76: Non-affective psychotic disorders diagnostic Read
Eu20213 [X]Schizophrenic catatonia res76: Non-affective psychotic disorders diagnostic Read
Eu20214 [X]Schizophrenic flexibilatis cerea res76: Non-affective psychotic disorders diagnostic Read
Eu20300 [X]Undifferentiated schizophrenia res76: Non-affective psychotic disorders diagnostic Read
Eu20311 [X]Atypical schizophrenia res76: Non-affective psychotic disorders diagnostic Read
Eu20500 [X]Residual schizophrenia res76: Non-affective psychotic disorders diagnostic Read
Eu20511 [X]Chronic undifferentiated schizophrenia res76: Non-affective psychotic disorders diagnostic Read
Eu20600 [X]Simple schizophrenia res76: Non-affective psychotic disorders diagnostic Read
Eu20y00 [X]Other schizophrenia res76: Non-affective psychotic disorders diagnostic Read
Eu20y12 [X]Schizophreniform disord NOS res76: Non-affective psychotic disorders diagnostic Read
Eu20y13 [X]Schizophrenifrm psychos NOS res76: Non-affective psychotic disorders diagnostic Read
Eu20z00 [X]Schizophrenia, unspecified res76: Non-affective psychotic disorders diagnostic Read
Eu21.00 [X]Schizotypal disorder res76: Non-affective psychotic disorders diagnostic Read
Eu21.11 [X]Latent schizophrenic reaction res76: Non-affective psychotic disorders diagnostic Read
Eu21.12 [X]Borderline schizophrenia res76: Non-affective psychotic disorders diagnostic Read
Eu21.13 [X]Latent schizophrenia res76: Non-affective psychotic disorders diagnostic Read
Eu21.14 [X]Prepsychotic schizophrenia res76: Non-affective psychotic disorders diagnostic Read
Eu21.15 [X]Prodromal schizophrenia res76: Non-affective psychotic disorders diagnostic Read
Eu21.16 [X]Pseudoneurotic schizophrenia res76: Non-affective psychotic disorders diagnostic Read
Eu21.17 [X]Pseudopsychopathic schizophrenia res76: Non-affective psychotic disorders diagnostic Read
Eu22.00 [X]Persistent delusional disorders res76: Non-affective psychotic disorders diagnostic Read
Eu22000 [X]Delusional disorder res76: Non-affective psychotic disorders diagnostic Read
Eu22011 [X]Paranoid psychosis res76: Non-affective psychotic disorders diagnostic Read
Eu22012 [X]Paranoid state res76: Non-affective psychotic disorders diagnostic Read
Eu22013 [X]Paraphrenia - late res76: Non-affective psychotic disorders diagnostic Read
Eu22014 [X]Sensitiver Beziehungswahn res76: Non-affective psychotic disorders diagnostic Read
Eu22015 [X]Paranoia res76: Non-affective psychotic disorders diagnostic Read
Eu22100 [X]Delusional misidentification syndrome res76: Non-affective psychotic disorders diagnostic Read
Eu22111 [X]Capgras syndrome res76: Non-affective psychotic disorders diagnostic Read
Eu22200 [X]Cotard syndrome res76: Non-affective psychotic disorders diagnostic Read
Eu22300 [X]Paranoid state in remission res76: Non-affective psychotic disorders diagnostic Read
Eu22y00 [X]Other persistent delusional disorders res76: Non-affective psychotic disorders diagnostic Read
Eu22y11 [X]Delusional dysmorphophobia res76: Non-affective psychotic disorders diagnostic Read
Eu22y12 [X]Involutional paranoid state res76: Non-affective psychotic disorders diagnostic Read
Eu22y13 [X]Paranoia querulans res76: Non-affective psychotic disorders diagnostic Read
Eu22z00 [X]Persistent delusional disorder, unspecified res76: Non-affective psychotic disorders diagnostic Read
Eu23.00 [X]Acute and transient psychotic disorders res76: Non-affective psychotic disorders diagnostic Read
Eu23000 [X]Acute polymorphic psychot disord without symp of schizoph res76: Non-affective psychotic disorders diagnostic Read
Eu23011 [X]Bouffee delirante res76: Non-affective psychotic disorders diagnostic Read
Eu23012 [X]Cycloid psychosis res76: Non-affective psychotic disorders diagnostic Read
Eu23100 [X]Acute polymorphic psychot disord with symp of schizophren res76: Non-affective psychotic disorders diagnostic Read
Eu23112 [X]Cycloid psychosis with symptoms of schizophrenia res76: Non-affective psychotic disorders diagnostic Read
Eu23200 [X]Acute schizophrenia-like psychotic disorder res76: Non-affective psychotic disorders diagnostic Read
Eu23211 [X]Brief schizophreniform disorder res76: Non-affective psychotic disorders diagnostic Read
Eu23212 [X]Brief schizophrenifrm psych res76: Non-affective psychotic disorders diagnostic Read
Eu23214 [X]Schizophrenic reaction res76: Non-affective psychotic disorders diagnostic Read
Eu23300 [X]Other acute predominantly delusional psychotic disorders res76: Non-affective psychotic disorders diagnostic Read
Eu23312 [X]Psychogenic paranoid psychosis res76: Non-affective psychotic disorders diagnostic Read
Eu23y00 [X]Other acute and transient psychotic disorders res76: Non-affective psychotic disorders diagnostic Read
Eu23z00 [X]Acute and transient psychotic disorder, unspecified res76: Non-affective psychotic disorders diagnostic Read
Eu23z11 [X]Brief reactive psychosis NOS res76: Non-affective psychotic disorders diagnostic Read
Eu23z12 [X]Reactive psychosis res76: Non-affective psychotic disorders diagnostic Read
Eu24.00 [X]Induced delusional disorder res76: Non-affective psychotic disorders diagnostic Read
Eu24.11 [X]Folie a deux res76: Non-affective psychotic disorders diagnostic Read
Eu24.12 [X]Induced paranoid disorder res76: Non-affective psychotic disorders diagnostic Read
Eu24.13 [X]Induced psychotic disorder res76: Non-affective psychotic disorders diagnostic Read
Eu25012 [X]Schizophreniform psychosis, manic type res76: Non-affective psychotic disorders diagnostic Read
Eu25112 [X]Schizophreniform psychosis, depressive type res76: Non-affective psychotic disorders diagnostic Read
Eu26.00 [X]Nonorganic psychosis in remission res76: Non-affective psychotic disorders diagnostic Read
Eu2y.00 [X]Other nonorganic psychotic disorders res76: Non-affective psychotic disorders diagnostic Read
Eu2y.11 [X]Chronic hallucinatory psychosis res76: Non-affective psychotic disorders diagnostic Read
Eu2z.00 [X]Unspecified nonorganic psychosis res76: Non-affective psychotic disorders diagnostic Read
Eu2z.11 [X]Psychosis NOS res76: Non-affective psychotic disorders diagnostic Read
F481K00 Visual hallucinations res76: Non-affective psychotic disorders symptom Read
R001.00 [D]Hallucinations res76: Non-affective psychotic disorders symptom Read
R001000 [D]Hallucinations, auditory res76: Non-affective psychotic disorders symptom Read
R001400 [D]Visual hallucinations res76: Non-affective psychotic disorders symptom Read
R001z00 [D]Hallucinations NOS res76: Non-affective psychotic disorders symptom Read
ZV11000 [V]Personal history of schizophrenia res76: Non-affective psychotic disorders diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH825/version/1729/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH825/version/1729/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH825', '1729', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH825/version/1729/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH825/version/1729/export/codes/?format=json
CSV site_root/phenotypes/PH825/version/1729/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH825', '1729', api_client=client)

Version History

Version
ID
Name Owner Publish date
1729 Non-Affective Psychotic Disorders ieuan.scanlon 2022-04-04 currently shown

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