Personality Disorders
Kathryn M Abel, Holly Hope, Eleanor Swift, Rosa Parisi, Darren M Ashcroft, Kyriaki Kosidov, Semre Su Osam, Christian Dolman, Mathias Pierce
PH826 / 1731 Clinical-Coded Phenotype
Overview
Phenotype TypeDisease or syndromeSexFemaleValid Event Date Range01/01/2005 - 31/12/2017Coding SystemRead codes v2Data SourcesCollectionsClinicalCodes RepositoryPhenotype LibraryTagsNo dataDefinition
Background:
Little information exists about the prevalence of children exposed to maternal mental illness. We aimed to estimate the prevalence of children and adolescents exposed to maternal mental illness in the UK between 2005 and 2017 using primary care data.
Methods:
In this national retrospective cohort study, we included children aged 0–16 years born between Jan 1, 1991, and Dec 31, 2015, who were linked to their mothers and registered on the primary care Clinical Practice Research Datalink (CPRD) between 2005 and 2017. We extracted data on diagnosis, symptoms, and therapy from the CRPD to define the following maternal mental illnesses: depression, anxiety, non-affective psychosis, affective psychosis, eating disorders, personality disorders, alcohol misuse disorder, and substance misuse disorder. We also extracted data on socioeconomic status from the Index of Multiple Deprivation 2010 and data on ethnicity from the Hospital Episode Statistics dataset. The main outcome was prevalence of maternal mental illness. Prevalence was calculated for each 2-year period of childhood (from age 0–<2 14–<16 16 a age analysis and by children cumulative estimate experiencing from illness incidence logistic marginal maternal mental model. of p predictions regression risk survival the to used using we years) years.<>
Findings:
We identified 783 710 children registered in the UK CPRD mother-baby link database, and included 547 747 children (381 685 mothers) in our analysis. Overall prevalence of maternal mental illness was 23·2% (95% CI 23·1–23·4), which increased during childhood (21·9%, 21·7–22·1 among the 0–<2 (21·9–22·4) (24·8–25·5) (26·7 (28·3%, (29·8%, (52·8–53·3).< 0–3 100 14–<16 16 2005 2007 2015 2017. 22·2% 25·1% 26·4–27·1). 26·8–27·8 27·3%, 27·8–28·8). 29·0–30·5). 53·1% age among and anxiety areas between by children cumulative depression deprived england, exposed from geographically, group group). highest illness illnesses. in incidence increased ireland maternal mental months most northern observed of p per person prevalence prevalent proportion risk the to vs was were year years,>
Interpretation:
One in four children aged 0–16 years are exposed to maternal mental illness and the prevalence of diagnosed and treated maternal mental illness is increasing. Policy makers and commissioners should consider this information and channel resources to target individuals in greatest need.
Implementation
Implementation
Clinical Code List
PUBLISHED - 122 Codes
Publication
Kathryn M Abel, Holly Hope, Eleanor Swift, Rosa Parisi, Darren M Ashcroft, Kyriaki Kosidov, Samre Su Osam, Christian Dolman, Mathias Pierce, Prevalence of maternal mental illness among children and adolescents in the UK between 2005 and 2017: a national retrospective cohort analysis. Lancet Public Health, 4, e291–300, 2019.
Citation Example
Kathryn M Abel, Holly Hope, Eleanor Swift, Rosa Parisi, Darren M Ashcroft, Kyriaki Kosidov, Semre Su Osam, Christian Dolman, Mathias Pierce. PH826 / 1731 - Personality Disorders. Phenotype Library [Online]. 04 April 2022. Available from: http://phenotypes.healthdatagateway.org/phenotypes/PH826/version/1731/detail/. [Accessed 31 October 2024]
API
To Export Phenotype Details:
Format API JSON site_root/api/v1/phenotypes/PH826/version/1731/detail/?format=json R Package library(ConceptLibraryClient)
# Connect to API
client = ConceptLibraryClient::Connection$new(public=TRUE)
# Get details of phenotype
phenotype_details = client$phenotypes$get_detail(
'PH826',
version_id=1731
)Py Package from pyconceptlibraryclient import Client
# Connect to API
client = Client(public=True)
# Get codelist of phenotype
phenotype_codelist = client.phenotypes.get_detail(
'PH826',
version_id=1731
)To Export Phenotype Code List:
Format API JSON site_root/api/v1/phenotypes/PH826/version/1731/export/codes/?format=json CSV site_root/phenotypes/PH826/version/1731/export/codes/ R Package library(ConceptLibraryClient)
# Connect to API
client = ConceptLibraryClient::Connection$new(public=TRUE)
# Get codelist of phenotype
phenotype_codelist = client$phenotypes$get_codelist(
'PH826',
version_id=1731
)Py Package from pyconceptlibraryclient import Client
# Connect to API
client = Client(public=True)
# Get codelist of phenotype
phenotype_codelist = client.phenotypes.get_codelist(
'PH826',
version_id=1731
)Version History