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Personality Disorders

Kathryn M Abel, Holly Hope, Eleanor Swift, Rosa Parisi, Darren M Ashcroft, Kyriaki Kosidov, Semre Su Osam, Christian Dolman, Mathias Pierce

Type
Disease or Syndrome
ID
PH826
Version ID
1731
Data Sources
Valid event data range
01/01/2005 - 31/12/2017
Sex
Female
Agreement Date
2019-06-30
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Background:

Little information exists about the prevalence of children exposed to maternal mental illness. We aimed to estimate the prevalence of children and adolescents exposed to maternal mental illness in the UK between 2005 and 2017 using primary care data.

Methods:

In this national retrospective cohort study, we included children aged 0–16 years born between Jan 1, 1991, and Dec 31, 2015, who were linked to their mothers and registered on the primary care Clinical Practice Research Datalink (CPRD) between 2005 and 2017. We extracted data on diagnosis, symptoms, and therapy from the CRPD to define the following maternal mental illnesses: depression, anxiety, non-affective psychosis, affective psychosis, eating disorders, personality disorders, alcohol misuse disorder, and substance misuse disorder. We also extracted data on socioeconomic status from the Index of Multiple Deprivation 2010 and data on ethnicity from the Hospital Episode Statistics dataset. The main outcome was prevalence of maternal mental illness. Prevalence was calculated for each 2-year period of childhood (from age 0–<2 to 14–<16 years) using marginal predictions from a logistic regression model. We used survival analysis to estimate the incidence and cumulative risk of children experiencing maternal mental illness by age 16 years.

Findings:

We identified 783 710 children registered in the UK CPRD mother-baby link database, and included 547 747 children (381 685 mothers) in our analysis. Overall prevalence of maternal mental illness was 23·2% (95% CI 23·1–23·4), which increased during childhood (21·9%, 21·7–22·1 among the 0–<2 year age group vs 27·3%, 26·8–27·8 among the 14–<16 year age group). Depression and anxiety were the most prevalent maternal mental illnesses. The proportion of children exposed to maternal mental illness increased from 22·2% (21·9–22·4) between 2005 and 2007 to 25·1% (24·8–25·5) between 2015 and 2017. Geographically, the highest prevalence of maternal mental illness was observed in Northern Ireland (29·8%, 29·0–30·5). In England, prevalence of maternal mental illness was highest among children in the most deprived areas (28·3%, 27·8–28·8). The incidence of maternal mental illness was highest between 0–3 months (26·7 per 100 person years, 26·4–27·1). By age 16 years, the cumulative risk of maternal mental illness was 53·1% (52·8–53·3).

Interpretation:

One in four children aged 0–16 years are exposed to maternal mental illness and the prevalence of diagnosed and treated maternal mental illness is increasing. Policy makers and commissioners should consider this information and channel resources to target individuals in greatest need.

Publications

  • Kathryn M Abel, Holly Hope, Eleanor Swift, Rosa Parisi, Darren M Ashcroft, Kyriaki Kosidov, Samre Su Osam, Christian Dolman, Mathias Pierce, Prevalence of maternal mental illness among children and adolescents in the UK between 2005 and 2017: a national retrospective cohort analysis. Lancet Public Health, 4, e291–300, 2019.

Clinical Code List

Rows: 122
Code Description Entity type Category Coding System (Read)
28L..00 O/E - impulsive behaviour res76: Personality disorders symptom Read
E21..00 Personality disorders res76: Personality disorders diagnostic Read
E21..11 Neurotic personality disorder res76: Personality disorders diagnostic Read
E210.00 Paranoid personality disorder res76: Personality disorders diagnostic Read
E211.00 Affective personality disorder res76: Personality disorders diagnostic Read
E211000 Unspecified affective personality disorder res76: Personality disorders diagnostic Read
E211100 Hypomanic personality disorder res76: Personality disorders diagnostic Read
E211300 Cyclothymic personality disorder res76: Personality disorders diagnostic Read
E211z00 Affective personality disorder NOS res76: Personality disorders diagnostic Read
E212.00 Schizoid personality disorder res76: Personality disorders diagnostic Read
E212000 Unspecified schizoid personality disorder res76: Personality disorders diagnostic Read
E212200 Schizotypal personality res76: Personality disorders diagnostic Read
E212z00 Schizoid personality disorder NOS res76: Personality disorders diagnostic Read
E213.00 Explosive personality disorder res76: Personality disorders diagnostic Read
E213.11 Aggressive personality res76: Personality disorders diagnostic Read
E214.00 Compulsive personality disorders res76: Personality disorders diagnostic Read
E214.11 Anancastic personality res76: Personality disorders diagnostic Read
E214000 Anankastic personality res76: Personality disorders diagnostic Read
E214100 Obsessional personality res76: Personality disorders diagnostic Read
E214z00 Compulsive personality disorder NOS res76: Personality disorders diagnostic Read
E215.00 Histrionic personality disorders res76: Personality disorders diagnostic Read
E215.11 Hysterical personality disorders res76: Personality disorders diagnostic Read
E215000 Unspecified histrionic personality disorder res76: Personality disorders diagnostic Read
E215100 Munchausen's syndrome res76: Personality disorders diagnostic Read
E215200 Emotionally unstable personality res76: Personality disorders diagnostic Read
E215z00 Histrionic personality disorder NOS res76: Personality disorders diagnostic Read
E216.00 Inadequate personality disorder res76: Personality disorders diagnostic Read
E216.11 Asthenic personality res76: Personality disorders diagnostic Read
E216.12 Dependent personality res76: Personality disorders diagnostic Read
E216.13 Labile personality res76: Personality disorders diagnostic Read
E217.00 Antisocial or sociopathic personality disorder res76: Personality disorders diagnostic Read
E217.11 Amoral personality res76: Personality disorders diagnostic Read
E21y.00 Other personality disorders res76: Personality disorders diagnostic Read
E21y000 Narcissistic personality disorder res76: Personality disorders diagnostic Read
E21y100 Avoidant personality disorder res76: Personality disorders diagnostic Read
E21y200 Borderline personality disorder res76: Personality disorders diagnostic Read
E21y300 Passive-aggressive personality disorder res76: Personality disorders diagnostic Read
E21y400 Eccentric personality disorder res76: Personality disorders diagnostic Read
E21y500 Immature personality disorder res76: Personality disorders diagnostic Read
E21y600 Masochistic personality disorder res76: Personality disorders diagnostic Read
E21y700 Psychoneurotic personality disorder res76: Personality disorders diagnostic Read
E21y711 Neurotic personality res76: Personality disorders diagnostic Read
E21yz00 Other personality disorder NOS res76: Personality disorders diagnostic Read
E21z.00 Personality disorder NOS res76: Personality disorders diagnostic Read
E21z.11 Psychopathic personality res76: Personality disorders diagnostic Read
E2C..00 Disturbance of conduct NEC res76: Personality disorders symptom Read
E2C0.00 Aggressive unsocial conduct disorder res76: Personality disorders symptom Read
E2C3100 Pathological gambling res76: Personality disorders diagnostic Read
E2C4.00 Mixed disturbance of conduct and emotion res76: Personality disorders symptom Read
Eu21.18 [X]Schizotypal personality disorder res76: Personality disorders diagnostic Read
Eu34011 [X]Affective personality disorder res76: Personality disorders diagnostic Read
Eu34012 [X]Cycloid personality res76: Personality disorders diagnostic Read
Eu34013 [X]Cyclothymic personality res76: Personality disorders diagnostic Read
Eu34112 [X]Depressive personality disorder res76: Personality disorders diagnostic Read
Eu6..00 [X]Disorders of adult personality and behaviour res76: Personality disorders diagnostic Read
Eu60.00 [X]Specific personality disorders res76: Personality disorders diagnostic Read
Eu60000 [X]Paranoid personality disorder res76: Personality disorders diagnostic Read
Eu60011 [X]Expansive paranoid personality disorder res76: Personality disorders diagnostic Read
Eu60013 [X]Querulant personality disorder res76: Personality disorders diagnostic Read
Eu60014 [X]Sensitive paranoid personality disorder res76: Personality disorders diagnostic Read
Eu60100 [X]Schizoid personality disorder res76: Personality disorders diagnostic Read
Eu60200 [X]Dissocial personality disorder res76: Personality disorders diagnostic Read
Eu60211 [X]Amoral personality disorder res76: Personality disorders diagnostic Read
Eu60212 [X]Antisocial personality disorder res76: Personality disorders diagnostic Read
Eu60213 [X]Asocial personality disorder res76: Personality disorders diagnostic Read
Eu60214 [X]Psychopathic personality disorder res76: Personality disorders diagnostic Read
Eu60215 [X]Sociopathic personality disorder res76: Personality disorders diagnostic Read
Eu60300 [X]Emotionally unstable personality disorder res76: Personality disorders diagnostic Read
Eu60311 [X]Aggressive personality disorder res76: Personality disorders diagnostic Read
Eu60312 [X]Borderline personality disorder res76: Personality disorders diagnostic Read
Eu60313 [X]Explosive personality disorder res76: Personality disorders diagnostic Read
Eu60400 [X]Histrionic personality disorder res76: Personality disorders diagnostic Read
Eu60411 [X]Hysterical personality disorder res76: Personality disorders diagnostic Read
Eu60412 [X]Psychoinfantile personality disorder res76: Personality disorders diagnostic Read
Eu60500 [X]Anankastic personality disorder res76: Personality disorders diagnostic Read
Eu60511 [X]Compulsive personality disorder res76: Personality disorders diagnostic Read
Eu60512 [X]Obsessional personality disorder res76: Personality disorders diagnostic Read
Eu60513 [X]Obsessive-compulsive personality disorder res76: Personality disorders diagnostic Read
Eu60600 [X]Anxious [avoidant] personality disorder res76: Personality disorders diagnostic Read
Eu60700 [X]Dependent personality disorder res76: Personality disorders diagnostic Read
Eu60711 [X]Asthenic personality disorder res76: Personality disorders diagnostic Read
Eu60712 [X]Inadequate personality disorder res76: Personality disorders diagnostic Read
Eu60713 [X]Passive personality disorder res76: Personality disorders diagnostic Read
Eu60714 [X]Self defeating personality disorder res76: Personality disorders diagnostic Read
Eu60800 [X]Addictive personality res76: Personality disorders diagnostic Read
Eu60y00 [X]Other specific personality disorders res76: Personality disorders diagnostic Read
Eu60y11 [X]Eccentric personality disorder res76: Personality disorders diagnostic Read
Eu60y12 [X]Haltlose type personality disorder res76: Personality disorders diagnostic Read
Eu60y13 [X]Immature personality disorder res76: Personality disorders diagnostic Read
Eu60y14 [X]Narcissistic personality disorder res76: Personality disorders diagnostic Read
Eu60y16 [X]Psychoneurotic personality disorder res76: Personality disorders diagnostic Read
Eu60z00 [X]Personality disorder, unspecified res76: Personality disorders diagnostic Read
Eu60z11 [X]Character neurosis NOS res76: Personality disorders diagnostic Read
Eu60z12 [X]Pathological personality NOS res76: Personality disorders diagnostic Read
Eu61.00 [X]Mixed and other personality disorders res76: Personality disorders diagnostic Read
Eu62.00 [X]Enduring personality change not attrib to brain damag/dis res76: Personality disorders diagnostic Read
Eu62000 [X]Enduring personality change after catastrophic experience res76: Personality disorders diagnostic Read
Eu62011 [X]Personality change after concentration camp experiences res76: Personality disorders diagnostic Read
Eu62012 [X]Personality change after disasters res76: Personality disorders diagnostic Read
Eu62013 [X]Personality change aft prolong captiv+possib/being killed res76: Personality disorders diagnostic Read
Eu62014 [X]Personlty chang aft expos life-threat sit/victim/terrorsm res76: Personality disorders diagnostic Read
Eu62015 [X]Personality change after torture res76: Personality disorders diagnostic Read
Eu62100 [X]Enduring personality change after psychiatric illness res76: Personality disorders diagnostic Read
Eu62y00 [X]Other enduring personality changes res76: Personality disorders diagnostic Read
Eu62y11 [X]Chronic pain personality syndrome res76: Personality disorders diagnostic Read
Eu62z00 [X]Enduring personality change, unspecified res76: Personality disorders diagnostic Read
Eu63.00 [X]Habit and impulse disorders res76: Personality disorders diagnostic Read
Eu63000 [X]Pathological gambling res76: Personality disorders diagnostic Read
Eu63011 [X]Compulsive gambling res76: Personality disorders diagnostic Read
Eu63100 [X]Pathological fire-setting res76: Personality disorders diagnostic Read
Eu63200 [X]Pathological stealing res76: Personality disorders diagnostic Read
Eu63300 [X]Trichotillomania res76: Personality disorders diagnostic Read
Eu63y00 [X]Other habit and impulse disorders res76: Personality disorders diagnostic Read
Eu63z00 [X]Habit and impulse disorder, unspecified res76: Personality disorders diagnostic Read
Eu6y.00 [X]Other disorders of adult personality and behaviour res76: Personality disorders diagnostic Read
Eu6y000 [X]Elaboration of physical symptoms for psychological reason res76: Personality disorders diagnostic Read
Eu6y100 [X]Intent product/feign of symptom/disab eith physical/psych res76: Personality disorders diagnostic Read
Eu6y111 [X] Munchausens syndrome res76: Personality disorders diagnostic Read
Eu6y200 [X]Munchausen's by proxy res76: Personality disorders diagnostic Read
Eu6y300 [X]Factitious disorder res76: Personality disorders diagnostic Read
Eu6yy00 [X]Other specified disorders of adult personality/behaviour res76: Personality disorders diagnostic Read
Eu6z.00 [X]Unspecified disorder of adult personality and behaviour res76: Personality disorders diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH826/version/1731/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH826/version/1731/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH826', '1731', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH826/version/1731/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH826/version/1731/export/codes/?format=json
CSV site_root/phenotypes/PH826/version/1731/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH826', '1731', api_client=client)

Version History

Version
ID
Name Owner Publish date
1731 Personality Disorders ieuan.scanlon 2022-04-04 currently shown

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