Phenotypes > Metformin

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Metformin

Matthew J Carr, Alison K Wright, Lalantha Leelarantha, Hood Thabit, Nicola Milne, Naresh Kanumilli, Darren M Ashcroft, Martin K Rutter

ID
PH836
Version ID
1751
Type
Drug
Data Sources
CPRD Aurum
Valid event data range
01/01/2010 - 29/02/2020
Sex
♀  Female ♂  Male
Agreement Date
2021-05-11
Coding system
GPRD product codes
Collections
ClinicalCodes Repository Phenotype Library
Tags
No tags

Definition

We generated a cohort of 25 million patients from 1831 UK general practices registered with the Clinical Practice Research Datalink (CPRD) Aurum (inEngland) and CPRD GOLD (in Northern Ireland, Scotland, and Wales) databases. The cohort included 14 929 251 patients (median age 41 years [IQR 25–59]; 7 461 565 [50·0%] of whom were women), who were followed between March 1 and Dec 10, 2020. We aimed to compare: (1) the UK-wide incidence of type 2 diabetes; (2) the frequency of HbA1c testing; and (3) mortality in people with type 2 diabetes, by nation, before and after the first nationwide COVID-19 lockdown, which began in March 23, 2020 (appendix pp 1–3). There were 790 377 (5·3%) people with type 2 diabetes in the cohort (median age 67 years (IQR 57–76); 348 515 (44·1%) of whom were women).

Publications

  • Matthew J Carr, Alison K Wright, Lalantha Leelarantha, Hood Thabit, Nicola Milne, Naresh Kanumilli, Darren M Ashcroft, Martin K Rutter, Impact of COVID-19 on diagnoses, monitoring, and mortality in people with type 2 diabetes in the UK. The Lancet Diabetes Endocrinology, 9, 2021.

Clinical Code List

Expand All  /  Collapse All
Rows: 90
Code Description Entity type Coding System (CPRD_product_code) Category
1.05988e+16 Glucient SR 750mg tablets (Consilient Health Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
1.05989e+16 Glucient SR 1000mg tablets (Consilient Health Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
1.06141e+16 Empagliflozin 5mg / Metformin 850mg tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
1.06142e+16 Empagliflozin 5mg / Metformin 1g tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
1.06143e+16 Empagliflozin 12.5mg / Metformin 850mg tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
1.06144e+16 Empagliflozin 12.5mg / Metformin 1g tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
1.06145e+16 Synjardy 5mg/850mg tablets (Boehringer Ingelheim Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
1.06146e+16 Synjardy 5mg/1000mg tablets (Boehringer Ingelheim Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
1.06147e+16 Synjardy 12.5mg/850mg tablets (Boehringer Ingelheim Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
1.06148e+16 Synjardy 12.5mg/1000mg tablets (Boehringer Ingelheim Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
1.17813e+16 Metformin 1g/5ml oral solution sugar free res166: Metformin (CPRD Aurum) CPRD_product_code drug
1.17814e+16 Metformin 850mg/5ml oral solution sugar free res166: Metformin (CPRD Aurum) CPRD_product_code drug
1.23265e+16 Meijumet 500mg modified-release tablets (Medreich Plc) res166: Metformin (CPRD Aurum) CPRD_product_code drug
1.23266e+16 Meijumet 750mg modified-release tablets (Medreich Plc) res166: Metformin (CPRD Aurum) CPRD_product_code drug
1.23267e+16 Meijumet 1000mg modified-release tablets (Medreich Plc) res166: Metformin (CPRD Aurum) CPRD_product_code drug
1.25931e+16 Yaltormin SR 500mg tablets (Wockhardt UK Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
1.25932e+16 Yaltormin SR 750mg tablets (Wockhardt UK Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
1.25933e+16 Yaltormin SR 1000mg tablets (Wockhardt UK Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
1.26644e+16 Metuxtan SR 500mg tablets (Accord Healthcare Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
1017140000000000.0 Orabet Tablets 500 mg res166: Metformin (CPRD Aurum) CPRD_product_code drug
1017240000000000.0 Orabet Tablets 850 mg res166: Metformin (CPRD Aurum) CPRD_product_code drug
2620240000000000.0 Metformin 500mg/5ml oral suspension res166: Metformin (CPRD Aurum) CPRD_product_code drug
2995140000000000.0 Avandamet 1mg/500mg tablets (GlaxoSmithKline UK Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
2995240000000000.0 Avandamet 2mg/500mg tablets (GlaxoSmithKline UK Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
3191340000000000.0 Rosiglitazone 1mg / Metformin 500mg tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
3191440000000000.0 Rosiglitazone 2mg / Metformin 500mg tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
3200540000000000.0 Rosiglitazone 2mg / Metformin 1g tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
3200640000000000.0 Rosiglitazone 4mg / Metformin 1g tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
3200740000000000.0 Avandamet 2mg/1000mg tablets (GlaxoSmithKline UK Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
3200840000000000.0 Avandamet 4mg/1000mg tablets (GlaxoSmithKline UK Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
3228140000000000.0 Metformin 500mg modified-release tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
3228240000000000.0 Glucophage SR 500mg tablets (Merck Serono Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
3890940000000000.0 Metformin Hydrochloride Sugar free suspension 500 mg/5 ml res166: Metformin (CPRD Aurum) CPRD_product_code drug
3982340000000000.0 Metformin 500mg/5ml oral solution sugar free res166: Metformin (CPRD Aurum) CPRD_product_code drug
3982440000000000.0 Metsol 500mg/5ml oral solution (Kappin Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
3983940000000000.0 Pioglitazone 15mg / Metformin 850mg tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
3984240000000000.0 Competact 15mg/850mg tablets (Takeda UK Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
4452340000000000.0 Vildagliptin 50mg / Metformin 850mg tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
4452440000000000.0 Vildagliptin 50mg / Metformin 1g tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
4452540000000000.0 Eucreas 50mg/1000mg tablets (Novartis Pharmaceuticals UK Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
4452640000000000.0 Eucreas 50mg/850mg tablets (Novartis Pharmaceuticals UK Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
4549140000000000.0 Metformin 750mg modified-release tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
4549240000000000.0 Glucophage SR 750mg tablets (Merck Serono Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
4945240000000000.0 Metformin 1g modified-release tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
4945340000000000.0 Glucophage SR 1000mg tablets (Merck Serono Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
4957740000000000.0 Bolamyn SR 500mg tablets (Teva UK Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
5007640000000000.0 Metformin 500mg oral powder sachets sugar free res166: Metformin (CPRD Aurum) CPRD_product_code drug
5007740000000000.0 Metformin 1g oral powder sachets sugar free res166: Metformin (CPRD Aurum) CPRD_product_code drug
5007840000000000.0 Glucophage 500mg oral powder sachets (Merck Serono Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
5007940000000000.0 Glucophage 1000mg oral powder sachets (Merck Serono Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
5128240000000000.0 Glucophage Tablets 1000 mg res166: Metformin (CPRD Aurum) CPRD_product_code drug
5132140000000000.0 Janumet Tablets 50 mg + 500 mg res166: Metformin (CPRD Aurum) CPRD_product_code drug
5132240000000000.0 Janumet 50mg/1000mg tablets (Merck Sharp & Dohme Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
5491940000000000.0 Amaryl M Tablets 1 mg + 250 mg res166: Metformin (CPRD Aurum) CPRD_product_code drug
5492040000000000.0 Amaryl M Tablets 2 mg + 500 mg res166: Metformin (CPRD Aurum) CPRD_product_code drug
5576040000000000.0 Metformin 1g / Sitagliptin 50mg tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
5997040000000000.0 Metformin 500mg/5ml oral solution res166: Metformin (CPRD Aurum) CPRD_product_code drug
6029840000000000.0 Metabet SR 500mg tablets (Morningside Healthcare Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
6279740000000000.0 Metabet SR 1000mg tablets (Morningside Healthcare Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
6391040000000000.0 Glucient SR 500mg tablets (Consilient Health Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
644941000000000.0 Glucophage 500mg tablets (Merck Serono Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
645041000000000.0 Glucophage 850mg tablets (Merck Serono Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
645541000000000.0 Glucamet Tablets 500 mg res166: Metformin (CPRD Aurum) CPRD_product_code drug
645641000000000.0 Glucamet Tablets 850 mg res166: Metformin (CPRD Aurum) CPRD_product_code drug
7874940000000000.0 Diagemet XL 500mg tablets (Genus Pharmaceuticals Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
8028440000000000.0 Galvus Met Tablets 850 mg + 50 mg res166: Metformin (CPRD Aurum) CPRD_product_code drug
8028540000000000.0 Galvus Met Tablets 1 gram + 50 mg res166: Metformin (CPRD Aurum) CPRD_product_code drug
8115740000000000.0 Linagliptin 2.5mg / Metformin 1g tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
8115840000000000.0 Linagliptin 2.5mg / Metformin 850mg tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
8115940000000000.0 Jentadueto 2.5mg/1000mg tablets (Boehringer Ingelheim Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
8116040000000000.0 Jentadueto 2.5mg/850mg tablets (Boehringer Ingelheim Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
8242540000000000.0 Saxagliptin 2.5mg / Metformin 850mg tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
8242640000000000.0 Saxagliptin 2.5mg / Metformin 1g tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
8242740000000000.0 Komboglyze 2.5mg/850mg tablets (AstraZeneca UK Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
8242840000000000.0 Komboglyze 2.5mg/1000mg tablets (AstraZeneca UK Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
8348940000000000.0 Bolamyn SR 1000mg tablets (Teva UK Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
8959840000000000.0 Alogliptin 12.5mg / Metformin 1g tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
8959940000000000.0 Vipdomet 12.5mg/1000mg tablets (Takeda UK Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
896941000000000.0 Metformin 500mg tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
897041000000000.0 Metformin 850mg tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
9106040000000000.0 Dapagliflozin 5mg / Metformin 1g tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
9106140000000000.0 Dapagliflozin 5mg / Metformin 850mg tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
9106240000000000.0 Xigduo 5mg/1000mg tablets (AstraZeneca UK Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
9106340000000000.0 Xigduo 5mg/850mg tablets (AstraZeneca UK Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
9230640000000000.0 Sukkarto SR 500mg tablets (Morningside Healthcare Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
9230840000000000.0 Sukkarto SR 1000mg tablets (Morningside Healthcare Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
9851540000000000.0 Canagliflozin 50mg / Metformin 1g tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
9851640000000000.0 Canagliflozin 50mg / Metformin 850mg tablets res166: Metformin (CPRD Aurum) CPRD_product_code drug
9851740000000000.0 Vokanamet 50mg/850mg tablets (Napp Pharmaceuticals Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug
9851840000000000.0 Vokanamet 50mg/1000mg tablets (Napp Pharmaceuticals Ltd) res166: Metformin (CPRD Aurum) CPRD_product_code drug

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH836/version/1751/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH836/version/1751/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH836', '1751', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH836/version/1751/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH836/version/1751/export/codes/?format=json
CSV site_root/phenotypes/PH836/version/1751/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH836', '1751', api_client=client)

Version History

Version
ID		 Name Owner Publish date
1751 Metformin ieuan.scanlon 2022-04-04 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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