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Dementia Alzheimer Vascular Mixed Nonspecific

Richard Hoile, Naji Tabet, Helen Smith, Stephen Bremner, Jackie Cassell, Elizabeth Ford

Type
Disease or Syndrome
ID
PH859
Version ID
1797
Data Sources
Valid event data range
01/01/2000 - 31/12/2012
Sex
Female, Male
Agreement Date
2020-09-01
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Objective:

There is evidence from neuroimaging studies of an association between insomnia and early dementia biomarkers, but observational studies have so far failed to show a clear association between insomnia and the later development of dementia. We investigated the association between dementia diagnosis and recording of insomnia symptoms 5–10 years earlier in primary care.

Method:

A case-control study using data from the Clinical Practice Research Datalink. 15,209 cases with dementia (either Alzheimer’s, vascular, mixed or non-specific subtypes) at least 65 years old at time of diagnosis, were matched with the same number of controls on year of birth and gender. We ascertained the presence of insomnia symptoms during a five-year period starting 10 years before the index date. Odds ratios for developing dementia were estimated using logistic regression after controlling for hypnotic exposure and physical and mental health comorbidities. Results: The adjusted odds ratio for dementia in those with previous insomnia was 1.34 (95% CI ¼ 1.20–1.50).

Conclusion:

There is an association between dementia and previous insomnia. It may be possible to incorporate insomnia into predictive tools for dementia.

Publications

  • Richard Hoile, Naji Tabet, Helen Smith, Stephen Bremmer,Jackie Cassell, Elizabeth Ford, Are symptoms of insomnia in primary care associated with subsequent onset of dementia A matched retrospective case-control study. Aging and Mental Health, 24(9):1466-1471, 2020.

Clinical Code List

Rows: 55
Code Description Entity type Category Coding System (Read)
1461.00 H/O: dementia res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
E00..11 Senile dementia res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
E00..12 Senile/presenile dementia res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
E000.00 Uncomplicated senile dementia res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
E001.00 Presenile dementia res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
E001000 Uncomplicated presenile dementia res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
E001100 Presenile dementia with delirium res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
E001200 Presenile dementia with paranoia res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
E001300 Presenile dementia with depression res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
E001z00 Presenile dementia NOS res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
E002.00 Senile dementia with depressive or paranoid fe... res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
E002000 Senile dementia with paranoia res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
E002100 Senile dementia with depression res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
E002z00 Senile dementia with depressive or paranoid fe... res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
E003.00 Senile dementia with delirium res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
E004.00 Arteriosclerotic dementia res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
E004.11 Multi infarct dementia res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
E004000 Uncomplicated arteriosclerotic dementia res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
E004100 Arteriosclerotic dementia with delirium res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
E004200 Arteriosclerotic dementia with paranoia res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
E004300 Arteriosclerotic dementia with depression res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
E004z00 Arteriosclerotic dementia NOS res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu00.00 [X]Dementia in Alzheimer's disease res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu00000 [X]Dementia in Alzheimer's disease with early ... res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu00011 [X]Presenile dementiaAlzheimer's type res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu00012 [X]Primary degen dementia Alzheimer's type p... res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu00013 [X]Alzheimer's disease type 2 res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu00100 [X]Dementia in Alzheimer's disease with late o... res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu00111 [X]Alzheimer's disease type 1 res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu00112 [X]Senile dementiaAlzheimer's type res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu00113 [X]Primary degen dementia of Alzheimer's type... res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu00200 [X]Dementia in Alzheimer's dis atypical or mi... res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu00z00 [X]Dementia in Alzheimer's disease unspecified res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu00z11 [X]Alzheimer's dementia unspec res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu01.00 [X]Vascular dementia res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu01.11 [X]Arteriosclerotic dementia res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu01000 [X]Vascular dementia of acute onset res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu01100 [X]Multi-infarct dementia res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu01111 [X]Predominantly cortical dementia res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu01200 [X]Subcortical vascular dementia res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu01300 [X]Mixed cortical and subcortical vascular dem... res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu01y00 [X]Other vascular dementia res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu01z00 [X]Vascular dementia unspecified res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu02y00 [X]Dementia in other specified diseases classi... res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu02z00 [X] Unspecified dementia res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu02z11 [X] Presenile dementia NOS res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu02z13 [X] Primary degenerative dementia NOS res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu02z14 [X] Senile dementia NOS res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu02z16 [X] Senile dementia depressed or paranoid type res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Eu04100 [X]Delirium superimposed on dementia res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
F110.00 Alzheimer's disease res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
F110000 Alzheimer's disease with early onset res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
F110100 Alzheimer's disease with late onset res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
F112.00 Senile degeneration of brain res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read
Fyu3000 [X]Other Alzheimer's disease res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH859/version/1797/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH859/version/1797/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH859', '1797', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH859/version/1797/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH859/version/1797/export/codes/?format=json
CSV site_root/phenotypes/PH859/version/1797/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH859', '1797', api_client=client)

Version History

Version
ID
Name Owner Publish date
1797 Dementia Alzheimer Vascular Mixed Nonspecific ieuan.scanlon 2022-04-04 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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