Objective:
There is evidence from neuroimaging studies of an association between insomnia and early dementia biomarkers, but observational studies have so far failed to show a clear association between insomnia and the later development of dementia. We investigated the association between dementia diagnosis and recording of insomnia symptoms 5–10 years earlier in primary care.
Method:
A case-control study using data from the Clinical Practice Research Datalink. 15,209 cases with dementia (either Alzheimer’s, vascular, mixed or non-specific subtypes) at least 65 years old at time of diagnosis, were matched with the same number of controls on year of birth and gender. We ascertained the presence of insomnia symptoms during a five-year period starting 10 years before the index date. Odds ratios for developing dementia were estimated using logistic regression after controlling for hypnotic exposure and physical and mental health comorbidities. Results: The adjusted odds ratio for dementia in those with previous insomnia was 1.34 (95% CI ¼ 1.20–1.50).
Conclusion:
There is an association between dementia and previous insomnia. It may be possible to incorporate insomnia into predictive tools for dementia.
Richard Hoile, Naji Tabet, Helen Smith, Stephen Bremmer,Jackie Cassell, Elizabeth Ford, Are symptoms of insomnia in primary care associated with subsequent onset of dementia A matched retrospective case-control study. Aging and Mental Health, 24(9):1466-1471, 2020.
Code | Description | Entity type | Category | Coding System (Read) |
---|---|---|---|---|
1461.00 | H/O: dementia | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
E00..11 | Senile dementia | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
E00..12 | Senile/presenile dementia | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
E000.00 | Uncomplicated senile dementia | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
E001.00 | Presenile dementia | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
E001000 | Uncomplicated presenile dementia | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
E001100 | Presenile dementia with delirium | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
E001200 | Presenile dementia with paranoia | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
E001300 | Presenile dementia with depression | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
E001z00 | Presenile dementia NOS | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
E002.00 | Senile dementia with depressive or paranoid fe... | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
E002000 | Senile dementia with paranoia | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
E002100 | Senile dementia with depression | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
E002z00 | Senile dementia with depressive or paranoid fe... | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
E003.00 | Senile dementia with delirium | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
E004.00 | Arteriosclerotic dementia | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
E004.11 | Multi infarct dementia | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
E004000 | Uncomplicated arteriosclerotic dementia | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
E004100 | Arteriosclerotic dementia with delirium | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
E004200 | Arteriosclerotic dementia with paranoia | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
E004300 | Arteriosclerotic dementia with depression | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
E004z00 | Arteriosclerotic dementia NOS | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu00.00 | [X]Dementia in Alzheimer's disease | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu00000 | [X]Dementia in Alzheimer's disease with early ... | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu00011 | [X]Presenile dementiaAlzheimer's type | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu00012 | [X]Primary degen dementia Alzheimer's type p... | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu00013 | [X]Alzheimer's disease type 2 | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu00100 | [X]Dementia in Alzheimer's disease with late o... | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu00111 | [X]Alzheimer's disease type 1 | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu00112 | [X]Senile dementiaAlzheimer's type | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu00113 | [X]Primary degen dementia of Alzheimer's type... | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu00200 | [X]Dementia in Alzheimer's dis atypical or mi... | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu00z00 | [X]Dementia in Alzheimer's disease unspecified | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu00z11 | [X]Alzheimer's dementia unspec | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu01.00 | [X]Vascular dementia | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu01.11 | [X]Arteriosclerotic dementia | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu01000 | [X]Vascular dementia of acute onset | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu01100 | [X]Multi-infarct dementia | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu01111 | [X]Predominantly cortical dementia | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu01200 | [X]Subcortical vascular dementia | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu01300 | [X]Mixed cortical and subcortical vascular dem... | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu01y00 | [X]Other vascular dementia | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu01z00 | [X]Vascular dementia unspecified | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu02y00 | [X]Dementia in other specified diseases classi... | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu02z00 | [X] Unspecified dementia | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu02z11 | [X] Presenile dementia NOS | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu02z13 | [X] Primary degenerative dementia NOS | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu02z14 | [X] Senile dementia NOS | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu02z16 | [X] Senile dementia depressed or paranoid type | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Eu04100 | [X]Delirium superimposed on dementia | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
F110.00 | Alzheimer's disease | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
F110000 | Alzheimer's disease with early onset | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
F110100 | Alzheimer's disease with late onset | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
F112.00 | Senile degeneration of brain | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
Fyu3000 | [X]Other Alzheimer's disease | res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific | diagnostic | Read |
To Export Phenotype Details:
Format | API |
---|---|
XML | site_root/api/v1/public/phenotypes/PH859/version/1797/detail/?format=xml |
JSON | site_root/api/v1/public/phenotypes/PH859/version/1797/detail/?format=json |
R Package |
|
To Export Phenotype Code List:
Format | API |
---|---|
XML | site_root/api/v1/public/phenotypes/PH859/version/1797/export/codes/?format=xml |
JSON | site_root/api/v1/public/phenotypes/PH859/version/1797/export/codes/?format=json |
CSV | site_root/phenotypes/PH859/version/1797/export/codes/ |
R Package |
|
Version ID |
Name | Owner | Publish date | |
---|---|---|---|---|
1797 | Dementia Alzheimer Vascular Mixed Nonspecific | ieuan.scanlon | 2022-04-04 | currently shown |
Export - export all codes into a csv file/JSON/XML for the current phenotype version.
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