Sleep Apnoea
Richard Hoile, Naji Tabet, Helen Smith, Stephen Bremner, Jackie Cassell, Elizabeth Ford
PH861 / 1801 Clinical-Coded Phenotype
Overview
Phenotype TypeDisease or syndromeSexBothValid Event Date Range01/01/2000 - 31/12/2012Coding SystemRead codes v2Data SourcesCollectionsClinicalCodes RepositoryPhenotype LibraryTagsNo dataDefinition
Objective:
There is evidence from neuroimaging studies of an association between insomnia and early dementia biomarkers, but observational studies have so far failed to show a clear association between insomnia and the later development of dementia. We investigated the association between dementia diagnosis and recording of insomnia symptoms 5–10 years earlier in primary care.
Method:
A case-control study using data from the Clinical Practice Research Datalink. 15,209 cases with dementia (either Alzheimer’s, vascular, mixed or non-specific subtypes) at least 65 years old at time of diagnosis, were matched with the same number of controls on year of birth and gender. We ascertained the presence of insomnia symptoms during a five-year period starting 10 years before the index date. Odds ratios for developing dementia were estimated using logistic regression after controlling for hypnotic exposure and physical and mental health comorbidities. Results: The adjusted odds ratio for dementia in those with previous insomnia was 1.34 (95% CI ¼ 1.20–1.50).
Conclusion:
There is an association between dementia and previous insomnia. It may be possible to incorporate insomnia into predictive tools for dementia.
Implementation
Implementation
Clinical Code List
PUBLISHED - 9 Codes
Publication
Richard Hoile, Naji Tabet, Helen Smith, Stephen Bremmer,Jackie Cassell, Elizabeth Ford, Are symptoms of insomnia in primary care associated with subsequent onset of dementia A matched retrospective case-control study. Aging and Mental Health, 24(9):1466-1471, 2020.
Citation Example
Richard Hoile, Naji Tabet, Helen Smith, Stephen Bremner, Jackie Cassell, Elizabeth Ford. PH861 / 1801 - Sleep Apnoea. Phenotype Library [Online]. 04 April 2022. Available from: http://phenotypes.healthdatagateway.org/phenotypes/PH861/version/1801/detail/. [Accessed 01 December 2024]
API
To Export Phenotype Details:
Format API JSON site_root/api/v1/phenotypes/PH861/version/1801/detail/?format=json R Package library(ConceptLibraryClient)
# Connect to API
client = ConceptLibraryClient::Connection$new(public=TRUE)
# Get details of phenotype
phenotype_details = client$phenotypes$get_detail(
'PH861',
version_id=1801
)Py Package from pyconceptlibraryclient import Client
# Connect to API
client = Client(public=True)
# Get codelist of phenotype
phenotype_codelist = client.phenotypes.get_detail(
'PH861',
version_id=1801
)To Export Phenotype Code List:
Format API JSON site_root/api/v1/phenotypes/PH861/version/1801/export/codes/?format=json CSV site_root/phenotypes/PH861/version/1801/export/codes/ R Package library(ConceptLibraryClient)
# Connect to API
client = ConceptLibraryClient::Connection$new(public=TRUE)
# Get codelist of phenotype
phenotype_codelist = client$phenotypes$get_codelist(
'PH861',
version_id=1801
)Py Package from pyconceptlibraryclient import Client
# Connect to API
client = Client(public=True)
# Get codelist of phenotype
phenotype_codelist = client.phenotypes.get_codelist(
'PH861',
version_id=1801
)Version History