Phenotype Library | phenotype: Sleep Apnoea

Sleep Apnoea

Richard Hoile, Naji Tabet, Helen Smith, Stephen Bremner, Jackie Cassell, Elizabeth Ford

PH861

Version ID

1801

Type

Disease or Syndrome

Data Sources

CPRD GOLD

Valid event data range

01/01/2000 - 31/12/2012

Sex

♀ Female ♂ Male

Agreement Date

2020-09-01

Coding system

Read codes v2

Collections

ClinicalCodes Repository Phenotype Library

Definition

Objective:

There is evidence from neuroimaging studies of an association between insomnia and early dementia biomarkers, but observational studies have so far failed to show a clear association between insomnia and the later development of dementia. We investigated the association between dementia diagnosis and recording of insomnia symptoms 5–10 years earlier in primary care.

Method:

A case-control study using data from the Clinical Practice Research Datalink. 15,209 cases with dementia (either Alzheimer’s, vascular, mixed or non-specific subtypes) at least 65 years old at time of diagnosis, were matched with the same number of controls on year of birth and gender. We ascertained the presence of insomnia symptoms during a five-year period starting 10 years before the index date. Odds ratios for developing dementia were estimated using logistic regression after controlling for hypnotic exposure and physical and mental health comorbidities. Results: The adjusted odds ratio for dementia in those with previous insomnia was 1.34 (95% CI ¼ 1.20–1.50).

Conclusion:

There is an association between dementia and previous insomnia. It may be possible to incorporate insomnia into predictive tools for dementia.

Publications

Richard Hoile, Naji Tabet, Helen Smith, Stephen Bremmer,Jackie Cassell, Elizabeth Ford, Are symptoms of insomnia in primary care associated with subsequent onset of dementia A matched retrospective case-control study. Aging and Mental Health, 24(9):1466-1471, 2020.

Clinical Code List

CSV

JSON

XML

Expand All / Collapse All

C2611/6635 Sleep Apnoea - Primary Care - Read codes v2

Rows: 9

Code	Description	Entity type	Category	Coding System (Read)
Fy03.00	Sleep apnoea	res78: Sleep apnoea	diagnostic	Read
Fy03.11	Obstructive sleep apnoea	res78: Sleep apnoea	diagnostic	Read
H5B..00	Sleep apnoea	res78: Sleep apnoea	diagnostic	Read
H5B0.00	Obstructive sleep apnoea	res78: Sleep apnoea	diagnostic	Read
R005100	[D]Insomnia with sleep apnoea	res78: Sleep apnoea	diagnostic	Read
R005300	[D]Hypersomnia with sleep apnoea	res78: Sleep apnoea	diagnostic	Read
R005311	[D]Sleep apnoea syndrome	res78: Sleep apnoea	diagnostic	Read
R005312	[D]Syndrome sleep apnoea	res78: Sleep apnoea	diagnostic	Read
R060400	[D]Apnoea	res78: Sleep apnoea	diagnostic	Read

API

To Export Phenotype Details:

Format	API
XML	site_root/api/v1/public/phenotypes/PH861/version/1801/detail/?format=xml
JSON	site_root/api/v1/public/phenotypes/PH861/version/1801/detail/?format=json
R Package	`# Download here library(ConceptLibraryClient) # Connect to API client = connect_to_API(public=TRUE) # Get details of phenotype details = get_phenotype_detail_by_version('PH861', '1801', api_client=client)`

To Export Phenotype Code List:

Format	API
XML	site_root/api/v1/public/phenotypes/PH861/version/1801/export/codes/?format=xml
JSON	site_root/api/v1/public/phenotypes/PH861/version/1801/export/codes/?format=json
CSV	site_root/phenotypes/PH861/version/1801/export/codes/
R Package	`# Download here library(ConceptLibraryClient) # Connect to API client = connect_to_API(public=TRUE) # Get codelists of phenotype codelists = get_phenotype_code_list('PH861', '1801', api_client=client)`

Version History

Version ID	Name	Owner	Publish date
1801	Sleep Apnoea	ieuan.scanlon	2022-04-04	currently shown