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Sleep Apnoea

Richard Hoile, Naji Tabet, Helen Smith, Stephen Bremner, Jackie Cassell, Elizabeth Ford

Type
Disease or Syndrome
ID
PH861
Version ID
1801
Data Sources
Valid event data range
01/01/2000 - 31/12/2012
Sex
Female, Male
Agreement Date
2020-09-01
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Objective:

There is evidence from neuroimaging studies of an association between insomnia and early dementia biomarkers, but observational studies have so far failed to show a clear association between insomnia and the later development of dementia. We investigated the association between dementia diagnosis and recording of insomnia symptoms 5–10 years earlier in primary care.

Method:

A case-control study using data from the Clinical Practice Research Datalink. 15,209 cases with dementia (either Alzheimer’s, vascular, mixed or non-specific subtypes) at least 65 years old at time of diagnosis, were matched with the same number of controls on year of birth and gender. We ascertained the presence of insomnia symptoms during a five-year period starting 10 years before the index date. Odds ratios for developing dementia were estimated using logistic regression after controlling for hypnotic exposure and physical and mental health comorbidities. Results: The adjusted odds ratio for dementia in those with previous insomnia was 1.34 (95% CI ¼ 1.20–1.50).

Conclusion:

There is an association between dementia and previous insomnia. It may be possible to incorporate insomnia into predictive tools for dementia.

Publications

  • Richard Hoile, Naji Tabet, Helen Smith, Stephen Bremmer,Jackie Cassell, Elizabeth Ford, Are symptoms of insomnia in primary care associated with subsequent onset of dementia A matched retrospective case-control study. Aging and Mental Health, 24(9):1466-1471, 2020.

Clinical Code List

Rows: 9
Code Description Entity type Category Coding System (Read)
Fy03.00 Sleep apnoea res78: Sleep apnoea diagnostic Read
Fy03.11 Obstructive sleep apnoea res78: Sleep apnoea diagnostic Read
H5B..00 Sleep apnoea res78: Sleep apnoea diagnostic Read
H5B0.00 Obstructive sleep apnoea res78: Sleep apnoea diagnostic Read
R005100 [D]Insomnia with sleep apnoea res78: Sleep apnoea diagnostic Read
R005300 [D]Hypersomnia with sleep apnoea res78: Sleep apnoea diagnostic Read
R005311 [D]Sleep apnoea syndrome res78: Sleep apnoea diagnostic Read
R005312 [D]Syndrome sleep apnoea res78: Sleep apnoea diagnostic Read
R060400 [D]Apnoea res78: Sleep apnoea diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH861/version/1801/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH861/version/1801/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH861', '1801', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH861/version/1801/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH861/version/1801/export/codes/?format=json
CSV site_root/phenotypes/PH861/version/1801/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH861', '1801', api_client=client)

Version History

Version
ID
Name Owner Publish date
1801 Sleep Apnoea ieuan.scanlon 2022-04-04 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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