Specific Dementias

Richard Hoile, Naji Tabet, Helen Smith, Stephen Bremner, Jackie Cassell, Elizabeth Ford

PH862 / 1803 Clinical-Coded Phenotype

  1. Overview

    Phenotype Type
    Disease or syndrome
    Sex
    Both
    Valid Event Date Range
    01/01/2000 - 31/12/2012
    Coding System
    Read codes v2
    Data Sources
    CPRD GOLD
    Collections
    ClinicalCodes RepositoryPhenotype Library
    Tags
    No data

  2. Definition

    Objective:

    There is evidence from neuroimaging studies of an association between insomnia and early dementia biomarkers, but observational studies have so far failed to show a clear association between insomnia and the later development of dementia. We investigated the association between dementia diagnosis and recording of insomnia symptoms 5–10 years earlier in primary care.

    Method:

    A case-control study using data from the Clinical Practice Research Datalink. 15,209 cases with dementia (either Alzheimer’s, vascular, mixed or non-specific subtypes) at least 65 years old at time of diagnosis, were matched with the same number of controls on year of birth and gender. We ascertained the presence of insomnia symptoms during a five-year period starting 10 years before the index date. Odds ratios for developing dementia were estimated using logistic regression after controlling for hypnotic exposure and physical and mental health comorbidities. Results: The adjusted odds ratio for dementia in those with previous insomnia was 1.34 (95% CI ¼ 1.20–1.50).

    Conclusion:

    There is an association between dementia and previous insomnia. It may be possible to incorporate insomnia into predictive tools for dementia.

  3. Implementation

    Implementation

    No data

  4. Clinical Code List

  5. Publication

    • Richard Hoile, Naji Tabet, Helen Smith, Stephen Bremmer,Jackie Cassell, Elizabeth Ford, Are symptoms of insomnia in primary care associated with subsequent onset of dementia A matched retrospective case-control study. Aging and Mental Health, 24(9):1466-1471, 2020.

    Citation Requirements

    No data

  6. API

    To Export Phenotype Details:

    FormatAPI
    JSON site_root/api/v1/phenotypes/PH862/version/1803/detail/?format=json
    R Package

    # Download here

    library(ConceptLibraryClient)


    # Connect to API

    client = ConceptLibraryClient::Connection$new(public=TRUE)


    # Get details of phenotype

    phenotype_details = client$phenotypes$get_detail(
     'PH862',
     version_id=1803
    )

    Py Package

    # Download here

    from pyconceptlibraryclient import Client


    # Connect to API

    client = Client(public=True)


    # Get codelist of phenotype

    phenotype_codelist = client.phenotypes.get_detail(
     'PH862',
     version_id=1803
    )

    To Export Phenotype Code List:

    FormatAPI
    JSON site_root/api/v1/phenotypes/PH862/version/1803/export/codes/?format=json
    CSV site_root/phenotypes/PH862/version/1803/export/codes/
    R Package

    # Download here

    library(ConceptLibraryClient)


    # Connect to API

    client = ConceptLibraryClient::Connection$new(public=TRUE)


    # Get codelist of phenotype

    phenotype_codelist = client$phenotypes$get_codelist(
     'PH862',
     version_id=1803
    )

    Py Package

    # Download here

    from pyconceptlibraryclient import Client


    # Connect to API

    client = Client(public=True)


    # Get codelist of phenotype

    phenotype_codelist = client.phenotypes.get_codelist(
     'PH862',
     version_id=1803
    )

  7. Version History

    Version IDNameOwnerPublish date
    1803 Specific Dementias ieuan.scanlon2022-04-04currently shown