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Hypertension (Drug Code)

Ellie Paige, Jessica Barret, David Stevens, Ruth H Keogh, Michael J Sweeting, Irwin Nazareth, Irene Peterson, Angela M Wood

ID
PH897
Version ID
1873
Type
Drug
Data Sources
Valid event data range
01/01/1997 - 18/01/2016
Sex
♀  Female ♂  Male
Agreement Date
2018-03-23
Coding system
Read codes v2
Collections
ClinicalCodes Repository Phenotype Library
Tags
No tags

Definition

The benefits of using electronic health records (EHRs) for disease risk screening and personalized health-care decisions are being increasingly recognized. Here we present a computationally feasible statistical approach with which to address the methodological challenges involved in utilizing historical repeat measures of multiple risk factors recorded in EHRs to systematically identify patients at high risk of future disease. The approach is principally based on a 2-stage dynamic landmark model. The first stage estimates current risk factor values from all available historical repeat risk factor measurements via landmark-age–specific multivariate linear mixed-effects models with correlated random intercepts, which account for sporadically recorded repeat measures, unobserved data, and measurement errors. The second stage predicts future disease risk from a sex-stratified Cox proportional hazardsmodel, with estimated current risk factor values from the first stage.We exemplify thesemethods by developing and validating a dynamic 10-year cardiovascular disease risk prediction model using primary-care EHRs for age, diabetes status, hypertension treatment, smoking status, systolic blood pressure, total cholesterol, and high-density lipoprotein cholesterol in 41,373 persons from 10 primary-care practices in England andWales contributing to The Health Improvement Network (1997–2016). Using cross-validation, the model was well-calibrated (Brier score = 0.041, 95% confidence interval: 0.039, 0.042) and had good discrimination (C-index = 0.768, 95%confidence interval: 0.759, 0.777).

Publications

  • Ellie Paige, Jessica Barret, David Stevens, Ruth H Keogh, Michael J Sweeting, Irwin Nazareth, Irene Peterson, Angela M Wood, Landmark Models for Optimizing the Use of Repeated Measurements of Risk Factors in Electronic Health Records to Predict Future Disease Risk. American Journal of Epidemiology, 187(7): 1530-1538, 2018.

Clinical Code List

Rows: 1155
Code Description Entity type Category Coding System (Read)
52835979 res67: Hypertension_Drug_Code drug Read
52839979 res67: Hypertension_Drug_Code drug Read
52855979 res67: Hypertension_Drug_Code drug Read
53673979 res67: Hypertension_Drug_Code drug Read
54852979 res67: Hypertension_Drug_Code drug Read
58058979 res67: Hypertension_Drug_Code drug Read
58096979 res67: Hypertension_Drug_Code drug Read
58319979 res67: Hypertension_Drug_Code drug Read
58543979 res67: Hypertension_Drug_Code drug Read
58544979 res67: Hypertension_Drug_Code drug Read
58545979 res67: Hypertension_Drug_Code drug Read
58600979 res67: Hypertension_Drug_Code drug Read
58688979 res67: Hypertension_Drug_Code drug Read
60706979 res67: Hypertension_Drug_Code drug Read
60707979 res67: Hypertension_Drug_Code drug Read
61229979 res67: Hypertension_Drug_Code drug Read
78352978 res67: Hypertension_Drug_Code drug Read
78354978 res67: Hypertension_Drug_Code drug Read
79827978 res67: Hypertension_Drug_Code drug Read
79850978 res67: Hypertension_Drug_Code drug Read
81099998 res67: Hypertension_Drug_Code drug Read
81128998 res67: Hypertension_Drug_Code drug Read
81450998 res67: Hypertension_Drug_Code drug Read
81451998 res67: Hypertension_Drug_Code drug Read
81453998 res67: Hypertension_Drug_Code drug Read
81454998 res67: Hypertension_Drug_Code drug Read
81456998 res67: Hypertension_Drug_Code drug Read
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81698998 res67: Hypertension_Drug_Code drug Read
81717998 res67: Hypertension_Drug_Code drug Read
81728998 res67: Hypertension_Drug_Code drug Read
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81764998 res67: Hypertension_Drug_Code drug Read
81777998 res67: Hypertension_Drug_Code drug Read
81787998 res67: Hypertension_Drug_Code drug Read
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81966998 res67: Hypertension_Drug_Code drug Read
82000998 res67: Hypertension_Drug_Code drug Read
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82134998 res67: Hypertension_Drug_Code drug Read
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82427998 res67: Hypertension_Drug_Code drug Read
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82734998 res67: Hypertension_Drug_Code drug Read
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82911998 res67: Hypertension_Drug_Code drug Read
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82914998 res67: Hypertension_Drug_Code drug Read
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83598998 res67: Hypertension_Drug_Code drug Read
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83605998 res67: Hypertension_Drug_Code drug Read
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83616998 res67: Hypertension_Drug_Code drug Read
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83623998 res67: Hypertension_Drug_Code drug Read
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83724998 res67: Hypertension_Drug_Code drug Read
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83832998 res67: Hypertension_Drug_Code drug Read
83835998 res67: Hypertension_Drug_Code drug Read
84035998 res67: Hypertension_Drug_Code drug Read
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84037998 res67: Hypertension_Drug_Code drug Read
84038998 res67: Hypertension_Drug_Code drug Read
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84040998 res67: Hypertension_Drug_Code drug Read
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84168998 res67: Hypertension_Drug_Code drug Read
84169998 res67: Hypertension_Drug_Code drug Read
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84189998 res67: Hypertension_Drug_Code drug Read
84253998 res67: Hypertension_Drug_Code drug Read
84266998 res67: Hypertension_Drug_Code drug Read
84299998 res67: Hypertension_Drug_Code drug Read
84300998 res67: Hypertension_Drug_Code drug Read
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84314998 res67: Hypertension_Drug_Code drug Read
84315998 res67: Hypertension_Drug_Code drug Read
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84649998 res67: Hypertension_Drug_Code drug Read
84734998 res67: Hypertension_Drug_Code drug Read
84790998 res67: Hypertension_Drug_Code drug Read
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84922998 res67: Hypertension_Drug_Code drug Read
84924998 res67: Hypertension_Drug_Code drug Read
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85014998 res67: Hypertension_Drug_Code drug Read
85015998 res67: Hypertension_Drug_Code drug Read
85016998 res67: Hypertension_Drug_Code drug Read
85017998 res67: Hypertension_Drug_Code drug Read
85018998 res67: Hypertension_Drug_Code drug Read
85019998 res67: Hypertension_Drug_Code drug Read
85025998 res67: Hypertension_Drug_Code drug Read
85046998 res67: Hypertension_Drug_Code drug Read
85218998 res67: Hypertension_Drug_Code drug Read
85219998 res67: Hypertension_Drug_Code drug Read
85375998 res67: Hypertension_Drug_Code drug Read
85395998 res67: Hypertension_Drug_Code drug Read
85396998 res67: Hypertension_Drug_Code drug Read
85407998 res67: Hypertension_Drug_Code drug Read
85414998 res67: Hypertension_Drug_Code drug Read
85416998 res67: Hypertension_Drug_Code drug Read
85460998 res67: Hypertension_Drug_Code drug Read
85496998 res67: Hypertension_Drug_Code drug Read
85512998 res67: Hypertension_Drug_Code drug Read
85527978 res67: Hypertension_Drug_Code drug Read
85775998 res67: Hypertension_Drug_Code drug Read
85791998 res67: Hypertension_Drug_Code drug Read
85792998 res67: Hypertension_Drug_Code drug Read
85850998 res67: Hypertension_Drug_Code drug Read
85887979 res67: Hypertension_Drug_Code drug Read
85900998 res67: Hypertension_Drug_Code drug Read
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86039998 res67: Hypertension_Drug_Code drug Read
86040998 res67: Hypertension_Drug_Code drug Read
86052998 res67: Hypertension_Drug_Code drug Read
86053998 res67: Hypertension_Drug_Code drug Read
86054998 res67: Hypertension_Drug_Code drug Read
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86090998 res67: Hypertension_Drug_Code drug Read
86092998 res67: Hypertension_Drug_Code drug Read
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86107998 res67: Hypertension_Drug_Code drug Read
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86124998 res67: Hypertension_Drug_Code drug Read
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86137998 res67: Hypertension_Drug_Code drug Read
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86990998 res67: Hypertension_Drug_Code drug Read
87016998 res67: Hypertension_Drug_Code drug Read
87021998 res67: Hypertension_Drug_Code drug Read
87022998 res67: Hypertension_Drug_Code drug Read
87027998 res67: Hypertension_Drug_Code drug Read
87028998 res67: Hypertension_Drug_Code drug Read
87064998 res67: Hypertension_Drug_Code drug Read
87152998 res67: Hypertension_Drug_Code drug Read
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87212998 res67: Hypertension_Drug_Code drug Read
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87214998 res67: Hypertension_Drug_Code drug Read
87226998 res67: Hypertension_Drug_Code drug Read
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87294998 res67: Hypertension_Drug_Code drug Read
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87370998 res67: Hypertension_Drug_Code drug Read
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87372998 res67: Hypertension_Drug_Code drug Read
87421998 res67: Hypertension_Drug_Code drug Read
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87424998 res67: Hypertension_Drug_Code drug Read
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87427998 res67: Hypertension_Drug_Code drug Read
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87509998 res67: Hypertension_Drug_Code drug Read
87510998 res67: Hypertension_Drug_Code drug Read
87511998 res67: Hypertension_Drug_Code drug Read
87512998 res67: Hypertension_Drug_Code drug Read
87515998 res67: Hypertension_Drug_Code drug Read
87539998 res67: Hypertension_Drug_Code drug Read
87572998 res67: Hypertension_Drug_Code drug Read
87573998 res67: Hypertension_Drug_Code drug Read
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89283997 res67: Hypertension_Drug_Code drug Read