Print

Statin

Ellie Paige, Jessica Barret, David Stevens, Ruth H Keogh, Michael J Sweeting, Irwin Nazareth, Irene Peterson, Angela M Wood

Type
Drug
ID
PH898
Version ID
1875
Data Sources
Valid event data range
01/01/1997 - 18/01/2016
Sex
Female, Male
Agreement Date
2018-03-23
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

The benefits of using electronic health records (EHRs) for disease risk screening and personalized health-care decisions are being increasingly recognized. Here we present a computationally feasible statistical approach with which to address the methodological challenges involved in utilizing historical repeat measures of multiple risk factors recorded in EHRs to systematically identify patients at high risk of future disease. The approach is principally based on a 2-stage dynamic landmark model. The first stage estimates current risk factor values from all available historical repeat risk factor measurements via landmark-age–specific multivariate linear mixed-effects models with correlated random intercepts, which account for sporadically recorded repeat measures, unobserved data, and measurement errors. The second stage predicts future disease risk from a sex-stratified Cox proportional hazardsmodel, with estimated current risk factor values from the first stage.We exemplify thesemethods by developing and validating a dynamic 10-year cardiovascular disease risk prediction model using primary-care EHRs for age, diabetes status, hypertension treatment, smoking status, systolic blood pressure, total cholesterol, and high-density lipoprotein cholesterol in 41,373 persons from 10 primary-care practices in England andWales contributing to The Health Improvement Network (1997–2016). Using cross-validation, the model was well-calibrated (Brier score = 0.041, 95% confidence interval: 0.039, 0.042) and had good discrimination (C-index = 0.768, 95%confidence interval: 0.759, 0.777).

Publications

  • Ellie Paige, Jessica Barret, David Stevens, Ruth H Keogh, Michael J Sweeting, Irwin Nazareth, Irene Peterson, Angela M Wood, Landmark Models for Optimizing the Use of Repeated Measurements of Risk Factors in Electronic Health Records to Predict Future Disease Risk. American Journal of Epidemiology, 187(7): 1530-1538, 2018.

Clinical Code List

Rows: 134
Code Description Entity type Category Coding System (Read)
57832979 res67: Statin_Code drug Read
57833979 res67: Statin_Code drug Read
57838979 res67: Statin_Code drug Read
58654979 res67: Statin_Code drug Read
58661979 res67: Statin_Code drug Read
58669979 res67: Statin_Code drug Read
58671979 res67: Statin_Code drug Read
61212979 res67: Statin_Code drug Read
61213979 res67: Statin_Code drug Read
61215979 res67: Statin_Code drug Read
61489979 res67: Statin_Code drug Read
62570979 res67: Statin_Code drug Read
62597979 res67: Statin_Code drug Read
64839979 res67: Statin_Code drug Read
79254979 res67: Statin_Code drug Read
81048998 res67: Statin_Code drug Read
81049998 res67: Statin_Code drug Read
81050998 res67: Statin_Code drug Read
81051998 res67: Statin_Code drug Read
83030998 res67: Statin_Code drug Read
83099998 res67: Statin_Code drug Read
86020998 res67: Statin_Code drug Read
86467998 res67: Statin_Code drug Read
86468998 res67: Statin_Code drug Read
86787998 res67: Statin_Code drug Read
86788998 res67: Statin_Code drug Read
86789998 res67: Statin_Code drug Read
86791998 res67: Statin_Code drug Read
86794998 res67: Statin_Code drug Read
86795998 res67: Statin_Code drug Read
86796998 res67: Statin_Code drug Read
86797998 res67: Statin_Code drug Read
86798998 res67: Statin_Code drug Read
87373998 res67: Statin_Code drug Read
87418998 res67: Statin_Code drug Read
87916998 res67: Statin_Code drug Read
87917998 res67: Statin_Code drug Read
87918998 res67: Statin_Code drug Read
88534998 res67: Statin_Code drug Read
89153996 res67: Statin_Code drug Read
89153997 res67: Statin_Code drug Read
89153998 res67: Statin_Code drug Read
89154996 res67: Statin_Code drug Read
89154997 res67: Statin_Code drug Read
89154998 res67: Statin_Code drug Read
89306996 res67: Statin_Code drug Read
89306997 res67: Statin_Code drug Read
89306998 res67: Statin_Code drug Read
89311996 res67: Statin_Code drug Read
89311997 res67: Statin_Code drug Read
89311998 res67: Statin_Code drug Read
90309998 res67: Statin_Code drug Read
90310998 res67: Statin_Code drug Read
90973998 res67: Statin_Code drug Read
91194998 res67: Statin_Code drug Read
92154990 res67: Statin_Code drug Read
92220998 res67: Statin_Code drug Read
92408998 res67: Statin_Code drug Read
92409998 res67: Statin_Code drug Read
92410998 res67: Statin_Code drug Read
92447998 res67: Statin_Code drug Read
92448997 res67: Statin_Code drug Read
92448998 res67: Statin_Code drug Read
92471998 res67: Statin_Code drug Read
92539998 res67: Statin_Code drug Read
92804996 res67: Statin_Code drug Read
92804997 res67: Statin_Code drug Read
92804998 res67: Statin_Code drug Read
92805997 res67: Statin_Code drug Read
92805998 res67: Statin_Code drug Read
93243996 res67: Statin_Code drug Read
93243997 res67: Statin_Code drug Read
93243998 res67: Statin_Code drug Read
93244996 res67: Statin_Code drug Read
93244997 res67: Statin_Code drug Read
93244998 res67: Statin_Code drug Read
93619996 res67: Statin_Code drug Read
93619997 res67: Statin_Code drug Read
93619998 res67: Statin_Code drug Read
93620996 res67: Statin_Code drug Read
93620997 res67: Statin_Code drug Read
93620998 res67: Statin_Code drug Read
93871990 res67: Statin_Code drug Read
94407990 res67: Statin_Code drug Read
94782990 res67: Statin_Code drug Read
94789990 res67: Statin_Code drug Read
94830990 res67: Statin_Code drug Read
94831990 res67: Statin_Code drug Read
94849990 res67: Statin_Code drug Read
94850990 res67: Statin_Code drug Read
94851990 res67: Statin_Code drug Read
94927990 res67: Statin_Code drug Read
95185990 res67: Statin_Code drug Read
95277990 res67: Statin_Code drug Read
95278990 res67: Statin_Code drug Read
95279990 res67: Statin_Code drug Read
95405990 res67: Statin_Code drug Read
95406990 res67: Statin_Code drug Read
95442990 res67: Statin_Code drug Read
95443990 res67: Statin_Code drug Read
95445990 res67: Statin_Code drug Read
95448990 res67: Statin_Code drug Read
95449990 res67: Statin_Code drug Read
95450990 res67: Statin_Code drug Read
95451990 res67: Statin_Code drug Read
95471990 res67: Statin_Code drug Read
95472990 res67: Statin_Code drug Read
95474990 res67: Statin_Code drug Read
95475990 res67: Statin_Code drug Read
95478990 res67: Statin_Code drug Read
95479990 res67: Statin_Code drug Read
95480990 res67: Statin_Code drug Read
95481990 res67: Statin_Code drug Read
95482990 res67: Statin_Code drug Read
95483990 res67: Statin_Code drug Read
95486990 res67: Statin_Code drug Read
95487990 res67: Statin_Code drug Read
95493990 res67: Statin_Code drug Read
95494990 res67: Statin_Code drug Read
95495990 res67: Statin_Code drug Read
95500990 res67: Statin_Code drug Read
95501990 res67: Statin_Code drug Read
95502990 res67: Statin_Code drug Read
95508990 res67: Statin_Code drug Read
95549990 res67: Statin_Code drug Read
95550990 res67: Statin_Code drug Read
95551990 res67: Statin_Code drug Read
97377979 res67: Statin_Code drug Read
97455979 res67: Statin_Code drug Read
97476979 res67: Statin_Code drug Read
97494979 res67: Statin_Code drug Read
97508979 res67: Statin_Code drug Read
97705979 res67: Statin_Code drug Read
99957979 res67: Statin_Code drug Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH898/version/1875/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH898/version/1875/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH898', '1875', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH898/version/1875/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH898/version/1875/export/codes/?format=json
CSV site_root/phenotypes/PH898/version/1875/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH898', '1875', api_client=client)

Version History

Version
ID
Name Owner Publish date
1875 Statin ieuan.scanlon 2022-04-04 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

Print - Print page.