The most recent alcohol consumption record in the five years before entry into the study was used to classify participants drinking behaviour. In light of current debates on the U/J-shaped relationship observed between alcohol consumption and aggregated CVD outcomes10 five drinking categories were defined including: (1) non-drinkers (Read66 codes such as "tee-total" and "non-drinkers"), former drinkers (those with codes for "stopped drinking alcohol"
and/or "ex-drinker"), occasional drinkers (those with codes for "drinks rarely" and/or "drinks occasionally"), current moderate drinkers (those who had a code for current alcohol consumer and an indicator of whether they drank within daily [32g or 24g of alcohol for men and women respectively]
and/or weekly [168g of alcohol for men and 112g for women] recommended sensible drinking limits for the UK at the time of observation69) and current heavy drinkers (defined as those who exceeded daily and/or weekly sensible drinking limits). We also utilised data fields with information entered on daily and/or weekly amount of alcohol consumed to define participants as non-drinkers, moderate drinkers (drank within daily and/or weekly guidelines) and heavy drinkers. Weekly alcohol data was available as a continuous variable, so we were able to classify consumption using standard thresholds
Data on daily alcohol intake was entered using categories of: (1) < 1 UK unit (8 grams of ethanol), (2) 1-2 UK units, (3) 3-6 UK units, (4) 7-9 UK units, and (5) > 9 UK units [Read codes 1362.00-1366.00], for which we defined moderate drinking as anything >1 UK
unit but less than 3 (women) or 7 (men) UK units. Unfortunately information on binge drinking was only available for a select minority of the cohort (~100 people) therefore a separate category for this drinking behaviour was not defined (but these patients were coded as heavy drinkers). We reclassified non-drinkers as former drinkers if they had any record of drinking recorded in their entire clinical record entered on CPRD prior to study entry (in cases whereby non-drinkers had no record of drinking before entering the study we assumed that they were not former drinkers). This resulted in 19,853 (out of 184,747; 10.7%) non-drinkers being recoded as former drinkers, a further 6,826 (3.7%)
participants were reclassified through having a positive history of alcohol abuse.
In the Clinical Practice Research Datalink (CPRD, primary care data) we extracted information on alcohol consumption based on:
We extracted alcohol unit intake information using the structured data part (entity type 5) of the additional table (units recorded in data2) field. We additionally extract information on intake through clinician-recorded classifications using Read terms (see below).
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Code | Description | CALIBER category |
---|---|---|
136..00 | Alcohol consumption | Drinker status not specified |
1361 | Teetotaller | Non drinker |
1361.11 | Non drinker alcohol | Non drinker |
1361.12 | Non-drinker alcohol | Non drinker |
1362.11 | Drinks rarely | Occasional drinker (less than once per week) |
1362.12 | Drinks occasionally | Occasional drinker (less than once per week) |
1367 | Stopped drinking alcohol | Ex drinker |
1368 | Alcohol consumption unknown | Drinker status not specified |
136A.00 | Ex-trivial drinker (<1u/day) | Ex drinker |
136B.00 | Ex-light drinker - (1-2u/day) | Ex drinker |
136C.00 | Ex-moderate drinker - (3-6u/d) | Ex drinker |
136D.00 | Ex-heavy drinker - (7-9u/day) | Ex drinker |
136E.00 | Ex-very heavy drinker-(>9u/d) | Ex drinker |
136F.00 | Spirit drinker | Current drinker |
136G.00 | Beer drinker | Current drinker |
136H.00 | Drinks beer and spirits | Current drinker |
136I.00 | Drinks wine | Current drinker |
136J.00 | Social drinker | Current drinker |
136K.00 | Alcohol intake above recommended sensible limits | Excess drinker |
136L.00 | Alcohol intake within recommended sensible limits | Current drinker |
136M.00 | Current non drinker | Non drinker |
136N.00 | Light drinker | Current drinker |
136O.00 | Moderate drinker | Current drinker |
136P.00 | Heavy drinker | Excess drinker |
136Q.00 | Very heavy drinker | Excess drinker |
136R.00 | Binge drinker | Binge drinker |
136S.00 | Hazardous alcohol use | Excess drinker |
136T.00 | Harmful alcohol use | Excess drinker |
136V.00 | Alcohol units per week | Drinker status not specified |
136W.00 | Alcohol misuse | Excess drinker |
136X.00 | Alcohol units consumed on heaviest drinking day | Drinker status not specified |
136Z.00 | Alcohol consumption NOS | Drinker status not specified |
13ZY.00 | Disqualified from driving due to excess alcohol | Excess drinker |
1D19.00 | Pain in lymph nodes after alcohol consumption | Current drinker |
2577 | O/E - breath - alcohol smell | Current drinker |
2577.11 | O/E - alcoholic breath | Current drinker |
9k19.00 | Alcohol assesment declined - enhanced services admin | Drinker status not specified |
9k19.11 | Alcohol assessment declined | Drinker status not specified |
E23..12 | Alcohol problem drinking | Excess drinker |
E250.00 | Nondependent alcohol abuse | Excess drinker |
E250.11 | Drunkenness NOS | Current drinker |
E250.12 | Hangover (alcohol) | Current drinker |
E250.13 | Inebriety NOS | Current drinker |
E250.14 | Intoxication - alcohol | Current drinker |
E250000 | Nondependent alcohol abuse, unspecified | Excess drinker |
E250100 | Nondependent alcohol abuse, continuous | Excess drinker |
E250200 | Nondependent alcohol abuse, episodic | Binge drinker |
E250300 | Nondependent alcohol abuse in remission | Excess drinker |
E250z00 | Nondependent alcohol abuse NOS | Excess drinker |
R103.00 | [D]Alcohol blood level excessive | Current drinker |
U81..00 | [X]Evid of alcohol involv determind by level of intoxication | Current drinker |
Z786200 | Drinking practice | Drinker status not specified |
ZV11311 | [V]Problems related to lifestyle alcohol use | Excess drinker |
ZV4KC00 | [V] Alcohol use | Drinker status not specified |
Code | Description | CALIBER category |
---|---|---|
1362 | Trivial drinker - <1u/day | Less than 1 unit/day |
1363 | Light drinker - 1-2u/day | 1-2 units/day |
1364 | Moderate drinker - 3-6u/day | 3-6 units/day |
1365 | Heavy drinker - 7-9u/day | 7-9 units/day |
1366 | Very heavy drinker - >9u/day | More than 9 units/day |
Code | Description | CALIBER category |
---|---|---|
1B1c.00 | Alcohol induced hallucinations | Mental Health |
C150500 | Alcohol-induced pseudo-Cushing's syndrome | Endocrine system |
E01..00 | Alcoholic psychoses | Mental Health |
E011.00 | Alcohol amnestic syndrome | Mental Health |
E011000 | Korsakov's alcoholic psychosis | Mental Health |
E011100 | Korsakov's alcoholic psychosis with peripheral neuritis | Mental Health |
E011200 | Wernicke-Korsakov syndrome | Mental Health |
E011z00 | Alcohol amnestic syndrome NOS | Mental Health |
E012.00 | Other alcoholic dementia | Mental Health |
E012.11 | Alcoholic dementia NOS | Mental Health |
E012000 | Chronic alcoholic brain syndrome | Nervous system |
E015.00 | Alcoholic paranoia | Mental Health |
E01y.00 | Other alcoholic psychosis | Mental Health |
E01yz00 | Other alcoholic psychosis NOS | Mental Health |
E01z.00 | Alcoholic psychosis NOS | Mental Health |
Eu10.00 | [X]Mental and behavioural disorders due to use of alcohol | Mental Health |
Eu10000 | [X]Mental & behav dis due to use alcohol: acute intoxication | Mental Health |
Eu10100 | [X]Mental and behav dis due to use of alcohol: harmful use | Mental Health |
Eu10500 | [X]Mental & behav dis due to use alcohol: psychotic disorder | Mental Health |
Eu10511 | [X]Alcoholic hallucinosis | Mental Health |
Eu10512 | [X]Alcoholic jealousy | Mental Health |
Eu10513 | [X]Alcoholic paranoia | Mental Health |
Eu10514 | [X]Alcoholic psychosis NOS | Mental Health |
Eu10600 | [X]Mental and behav dis due to use alcohol: amnesic syndrome | Mental Health |
Eu10611 | [X]Korsakov's psychosis, alcohol induced | Mental Health |
Eu10700 | [X]Men & behav dis due alcoh: resid & late-onset psychot dis | Mental Health |
Eu10711 | [X]Alcoholic dementia NOS | Mental Health |
Eu10712 | [X]Chronic alcoholic brain syndrome | Nervous system |
Eu10y00 | [X]Men & behav dis due to use alcohol: oth men & behav dis | Mental Health |
Eu10z00 | [X]Ment & behav dis due use alcohol: unsp ment & behav dis | Mental Health |
F11x000 | Cerebral degeneration due to alcoholism | Nervous system |
F11x011 | Alcoholic encephalopathy | Nervous system |
F144000 | Cerebellar ataxia due to alcoholism | Nervous system |
F25B.00 | Alcohol-induced epilepsy | Nervous system |
F375.00 | Alcoholic polyneuropathy | Nervous system |
F394100 | Alcoholic myopathy | Circulatory system |
G555.00 | Alcoholic cardiomyopathy | Circulatory system |
G852300 | Oesophageal varices in alcoholic cirrhosis of the liver | Digestive system |
J153.00 | Alcoholic gastritis | Digestive system |
J610.00 | Alcoholic fatty liver | Digestive system |
J611.00 | Acute alcoholic hepatitis | Digestive system |
J612.00 | Alcoholic cirrhosis of liver | Digestive system |
J612000 | Alcoholic fibrosis and sclerosis of liver | Digestive system |
J613.00 | Alcoholic liver damage unspecified | Digestive system |
J613000 | Alcoholic hepatic failure | Digestive system |
J617.00 | Alcoholic hepatitis | Digestive system |
J617000 | Chronic alcoholic hepatitis | Digestive system |
J671000 | Alcohol-induced chronic pancreatitis | Digestive system |
To Export Phenotype Details:
Format | API |
---|---|
XML | site_root/api/v1/public/phenotypes/PH9/version/1510/detail/?format=xml |
JSON | site_root/api/v1/public/phenotypes/PH9/version/1510/detail/?format=json |
R Package |
|
To Export Phenotype Code List:
Format | API |
---|---|
XML | site_root/api/v1/public/phenotypes/PH9/version/1510/export/codes/?format=xml |
JSON | site_root/api/v1/public/phenotypes/PH9/version/1510/export/codes/?format=json |
CSV | site_root/phenotypes/PH9/version/1510/export/codes/ |
R Package |
|
Version ID |
Name | Owner | Publish date | |
---|---|---|---|---|
1510 | Alcohol Consumption | ieuan.scanlon | 2021-10-19 | currently shown |
Export - export all codes into a csv file/JSON/XML for the current phenotype version.
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