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Sore Throat

Victoria Palin, Anna Molter, Miguel Belmonte, Darren M Ashcroft, Andrew White, William Welfare, Tjeerd van Staa

Type
Disease or Syndrome
ID
PH905
Version ID
1889
Data Sources
Valid event data range
01/01/2000 - 30/06/2015
Sex
Female, Male
Agreement Date
2019-04-30
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Objectives:

To examine variations across general practices and factors associated with antibiotic prescribing for common infections in UK primary care to identify potential targets for improvement and optimization of prescribing.

Methods:

Oral antibiotic prescribing for common infections was analysed using anonymized UK primary care electronic health records between 2000 and 2015 using the Clinical Practice Research Datalink (CPRD). The rate of prescribing for each condition was observed over time and mean change points were compared with national guideline updates. Any correlation between the rate of prescribing for each infectious condition was estimated within a practice. Predictors of prescribing were estimated using logistic regression in a matched patient cohort (1:1 by age, sex and calendar time).

Results:

Over 8 million patient records were examined in 587 UK general practices. Practices varied considerably in their propensity to prescribe antibiotics and this variance increased over time. Change points in prescribing did not reflect updates to national guidelines. Prescribing levels within practices were not consistent for different infectious conditions. A history of antibiotic use significantly increased the risk of receiving a subsequent antibiotic (by 22%–48% for patients with three or more antibiotic prescriptions in the past 12months), as did higher BMI, history of smoking and flu vaccinations. Other drivers for receiving an antibiotic varied considerably for each condition.

Conclusions:

Large variability in antibiotic prescribing between practices and within practices was observed. Prescribing guidelines alone do not positively influence a change in prescribing, suggesting more targeted interventions are required to optimize antibiotic prescribing in the UK.

Publications

  • Victoria Palin, Anna Molter, Darren M Ashcroft, Andrew White, William Welfare, Tjeerd van Staa, Antibiotic prescribing for common infections in UK general practice variability and drivers. Journal of Antimicrobial Chemotherapy, 74:2440-2450, 2019.

Clinical Code List

Rows: 35
Code Description Entity type Category Coding System (Read)
1C9..00 Sore throat symptom res70: Sore throat diagnostic Read
1C9..11 Throat soreness res70: Sore throat diagnostic Read
1C9Z.00 Sore throat symptom NOS res70: Sore throat diagnostic Read
AA1..00 Vincent's angina res70: Sore throat diagnostic Read
AA1..11 Trench mouth res70: Sore throat diagnostic Read
AA10.00 Vincent's stomatitis res70: Sore throat diagnostic Read
AA11.00 Vincent's gingivitis res70: Sore throat diagnostic Read
AA12.00 Vincent's pharyngitis res70: Sore throat diagnostic Read
AA1z.00 Vincent's angina NOS res70: Sore throat diagnostic Read
AA1z.11 Vincent's laryngitis res70: Sore throat diagnostic Read
AA1z.12 Vincent's tonsillitis res70: Sore throat diagnostic Read
H02..00 Acute pharyngitis res70: Sore throat diagnostic Read
H02..11 Sore throat NOS res70: Sore throat diagnostic Read
H02..12 Viral sore throat NOS res70: Sore throat diagnostic Read
H02..13 Throat infection - pharyngitis res70: Sore throat diagnostic Read
H021.00 Acute phlegmonous pharyngitis res70: Sore throat diagnostic Read
H022.00 Acute ulcerative pharyngitis res70: Sore throat diagnostic Read
H023.00 Acute bacterial pharyngitis res70: Sore throat diagnostic Read
H023z00 Acute bacterial pharyngitis NOS res70: Sore throat diagnostic Read
H02z.00 Acute pharyngitis NOS res70: Sore throat diagnostic Read
H03..00 Acute tonsillitis res70: Sore throat diagnostic Read
H03..11 Throat infection - tonsillitis res70: Sore throat diagnostic Read
H03..12 Tonsillitis res70: Sore throat diagnostic Read
H030.00 Acute erythematous tonsillitis res70: Sore throat diagnostic Read
H031.00 Acute follicular tonsillitis res70: Sore throat diagnostic Read
H032.00 Acute ulcerative tonsillitis res70: Sore throat diagnostic Read
H033.00 Acute catarrhal tonsillitis res70: Sore throat diagnostic Read
H035.00 Acute bacterial tonsillitis res70: Sore throat diagnostic Read
H035100 Acute staphylococcal tonsillitis res70: Sore throat diagnostic Read
H035z00 Acute bacterial tonsillitis NOS res70: Sore throat diagnostic Read
H037.00 Recurrent acute tonsillitis res70: Sore throat diagnostic Read
H03z.00 Acute tonsillitis NOS res70: Sore throat diagnostic Read
H14y500 Caseous tonsillitis res70: Sore throat diagnostic Read
H14y600 Lingular tonsillitis res70: Sore throat diagnostic Read
R041.00 [D]Throat pain res70: Sore throat diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH905/version/1889/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH905/version/1889/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH905', '1889', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH905/version/1889/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH905/version/1889/export/codes/?format=json
CSV site_root/phenotypes/PH905/version/1889/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH905', '1889', api_client=client)

Version History

Version
ID
Name Owner Publish date
1889 Sore Throat ieuan.scanlon 2022-04-04 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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