Phenotype Library | phenotype: Alcohol-Related Mortality

Alcohol-Related Mortality

Rosa Parisi, Roger T. Webb, Mathew J. Carr, Kieran J. Moriarty, Elise Kleyn, Christopher E. M. Griffiths, Darren M. Ashcroft

PH908

Version ID

1895

Type

Disease or Syndrome

Data Sources

CPRD GOLD

Valid event data range

01/01/1998 - 03/03/2014

Sex

♀ Female ♂ Male

Agreement Date

2017-09-15

Coding system

ICD10 codes ICD9 codes

Collections

ClinicalCodes Repository Phenotype Library

Definition

IMPORTANCE:

People diagnosed with psoriasis have an increased risk of premature mortality, but the underlying reasons for this mortality gap are unclear.

OBJECTIVE:

To investigate whether patients with psoriasis have an elevated risk of alcohol-related mortality.

DESIGN, SETTING, AND PARTICIPANTS:

An incident cohort of patients with psoriasis aged 18 years and older was delineated for 1998 through 2014 using the Clinical Practice Research atalink (CPRD) and linked to Hospital Episode Statistics (HES) and Office for National tatistics (ONS) mortality records. Patients with psoriasis were matched with up to 20 comparison patients without psoriasis on age, sex, and general practice.

MAIN OUTCOMES AND MEASURES:

Alcohol-related deathswere ascertained via the Office for National Statistics mortality records. A stratified Cox proportional hazard model was used to estimate the cause-specific hazard ratio for alcohol-related death, with adjustment for socioeconomic status.

RESULTS:

The cohort included 55 537 with psoriasis and 854 314 patients without psoriasis. Median (interquartile) age at index date was 47 (27) years; 408 230 of total patients (44.9%) were men. During a median (IQR) of 4.4 (6.2) years of follow-up, the alcohol-related mortality rate was 4.8 per 10 000 person-years (95%CI, 4.1-5.6; n = 152) for the psoriasis cohort, vs 2.5 per 10 000 (95%CI, 2.4- 2.7; n = 1118) for the comparison cohort. The hazard ratio for alcohol-related death in patients with psoriasis was 1.58 (95%CI, 1.31-1.91), and the predominant causes of alcohol-related deaths were alcoholic liver disease (65.1%), fibrosis and cirrhosis of the liver (23.7%), and mental and behavioral disorders due to alcohol (7.9%).

CONCLUSIONS AND RELEVANCE:

People with psoriasis have approximately a 60%greater risk of dying due to alcohol-related causes compared with peers of the same age and sex in the general population. This appears to be a key contributor to the premature mortality gap. These findings call for routine screening, identification and treatment, using the Alcohol Use Disorders Identification Test (AUDIT-C) in both primary and secondary care to detect alcohol consumption and misuse among people diagnosed with psoriasis.

Publications

Rosa Parisi, Roger T. Webb, Mathew J. Carr, Kieran J. Moriarty, Elise Kleyn, Christopher E. M. Griffiths, Darren M. Ashcroft, Alcohol-Related Mortality in Patients With Psoriasis A Population-Based Cohort Study. JAMA Dermatology, 153(12):1256-1262, 2017.

Clinical Code List

CSV

JSON

XML

Expand All / Collapse All

C2680/6773 Alcohol-Related Mortality - Primary Care - ICD9 codes

Rows: 6

Code	Description	Entity type	Coding System (ICD-10 ICD-9)	Category
291	Alcoholic psychoses	res61: Alcohol-related mortality	ICD-9	diagnostic
303	Alcohol dependence syndrome	res61: Alcohol-related mortality	ICD-9	diagnostic
305	Non-dependent abuse of alcohol	res61: Alcohol-related mortality	ICD-9	diagnostic
425.5	Alcoholic cardiomyopathy	res61: Alcohol-related mortality	ICD-9	diagnostic
571	Chronic liver disease and cirrhosis (Excluding 571.6 - Biliary cirrhosis)	res61: Alcohol-related mortality	ICD-9	diagnostic
E860	Accidental poisoning by alcohol	res61: Alcohol-related mortality	ICD-9	diagnostic

C2681/6775 Alcohol-Related Mortality - Primary Care - ICD10 codes

Rows: 12

Code	Description	Entity type	Coding System (ICD-10 ICD-9)	Category
F10	Mental and behavioural disorders due to use of alcohol	res61: Alcohol-related mortality	ICD-10	diagnostic
G31.2	Degeneration of nervous system due to alcohol	res61: Alcohol-related mortality	ICD-10	diagnostic
G62.1	Alcoholic polyneuropathy	res61: Alcohol-related mortality	ICD-10	diagnostic
I42.6	Alcoholic cardiomyopathy	res61: Alcohol-related mortality	ICD-10	diagnostic
K29.2	Alcoholic gastritis	res61: Alcohol-related mortality	ICD-10	diagnostic
K70	Alcoholic liver disease	res61: Alcohol-related mortality	ICD-10	diagnostic
K73	Chronic hepatitis, not elsewhere classified	res61: Alcohol-related mortality	ICD-10	diagnostic
K74	Fibrosis and cirrhosis of liver (Excluding K74.3?K74.5 - Biliary cirrhosis)	res61: Alcohol-related mortality	ICD-10	diagnostic
K86.0	Alcohol induced chronic pancreatitis	res61: Alcohol-related mortality	ICD-10	diagnostic
X45	Accidental poisoning by and exposure to alcohol	res61: Alcohol-related mortality	ICD-10	diagnostic
X65	Intentional self-poisoning by and exposure to alcohol	res61: Alcohol-related mortality	ICD-10	diagnostic
Y15	Poisoning by and exposure to alcohol, undetermined intent	res61: Alcohol-related mortality	ICD-10	diagnostic

API

To Export Phenotype Details:

Format	API
XML	site_root/api/v1/public/phenotypes/PH908/version/1895/detail/?format=xml
JSON	site_root/api/v1/public/phenotypes/PH908/version/1895/detail/?format=json
R Package	`# Download here library(ConceptLibraryClient) # Connect to API client = connect_to_API(public=TRUE) # Get details of phenotype details = get_phenotype_detail_by_version('PH908', '1895', api_client=client)`

To Export Phenotype Code List:

Format	API
XML	site_root/api/v1/public/phenotypes/PH908/version/1895/export/codes/?format=xml
JSON	site_root/api/v1/public/phenotypes/PH908/version/1895/export/codes/?format=json
CSV	site_root/phenotypes/PH908/version/1895/export/codes/
R Package	`# Download here library(ConceptLibraryClient) # Connect to API client = connect_to_API(public=TRUE) # Get codelists of phenotype codelists = get_phenotype_code_list('PH908', '1895', api_client=client)`

Version History

Version ID	Name	Owner	Publish date
1895	Alcohol-Related Mortality	ieuan.scanlon	2022-04-04	currently shown