Phenotype Library | phenotype: Psoriasis

Psoriasis

Rosa Parisi, Roger T. Webb, Mathew J. Carr, Kieran J. Moriarty, Elise Kleyn, Christopher E. M. Griffiths, Darren M. Ashcroft

PH911

Version ID

1901

Type

Disease or Syndrome

Data Sources

CPRD GOLD

Valid event data range

01/01/1998 - 03/03/2014

Sex

♀ Female ♂ Male

Agreement Date

2017-09-15

Coding system

Read codes v2

Collections

ClinicalCodes Repository Phenotype Library

Definition

IMPORTANCE:

People diagnosed with psoriasis have an increased risk of premature mortality, but the underlying reasons for this mortality gap are unclear.

OBJECTIVE:

To investigate whether patients with psoriasis have an elevated risk of alcohol-related mortality.

DESIGN, SETTING, AND PARTICIPANTS:

An incident cohort of patients with psoriasis aged 18 years and older was delineated for 1998 through 2014 using the Clinical Practice Research atalink (CPRD) and linked to Hospital Episode Statistics (HES) and Office for National tatistics (ONS) mortality records. Patients with psoriasis were matched with up to 20 comparison patients without psoriasis on age, sex, and general practice.

MAIN OUTCOMES AND MEASURES:

Alcohol-related deathswere ascertained via the Office for National Statistics mortality records. A stratified Cox proportional hazard model was used to estimate the cause-specific hazard ratio for alcohol-related death, with adjustment for socioeconomic status.

RESULTS:

The cohort included 55 537 with psoriasis and 854 314 patients without psoriasis. Median (interquartile) age at index date was 47 (27) years; 408 230 of total patients (44.9%) were men. During a median (IQR) of 4.4 (6.2) years of follow-up, the alcohol-related mortality rate was 4.8 per 10 000 person-years (95%CI, 4.1-5.6; n = 152) for the psoriasis cohort, vs 2.5 per 10 000 (95%CI, 2.4- 2.7; n = 1118) for the comparison cohort. The hazard ratio for alcohol-related death in patients with psoriasis was 1.58 (95%CI, 1.31-1.91), and the predominant causes of alcohol-related deaths were alcoholic liver disease (65.1%), fibrosis and cirrhosis of the liver (23.7%), and mental and behavioral disorders due to alcohol (7.9%).

CONCLUSIONS AND RELEVANCE:

People with psoriasis have approximately a 60%greater risk of dying due to alcohol-related causes compared with peers of the same age and sex in the general population. This appears to be a key contributor to the premature mortality gap. These findings call for routine screening, identification and treatment, using the Alcohol Use Disorders Identification Test (AUDIT-C) in both primary and secondary care to detect alcohol consumption and misuse among people diagnosed with psoriasis.

Publications

Rosa Parisi, Roger T. Webb, Mathew J. Carr, Kieran J. Moriarty, Elise Kleyn, Christopher E. M. Griffiths, Darren M. Ashcroft, Alcohol-Related Mortality in Patients With Psoriasis A Population-Based Cohort Study. JAMA Dermatology, 153(12):1256-1262, 2017.

Clinical Code List

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C2686/6785 Psoriasis - Primary Care - Read codes v2

Rows: 24

Code	Description	Entity type	Category	Coding System (Read)
M16..00	Psoriasis and similar disorders	res61: psoriasis	diagnostic	Read
M161.00	Other psoriasis	res61: psoriasis	diagnostic	Read
M161000	Psoriasis unspecified	res61: psoriasis	diagnostic	Read
M161100	Psoriasis annularis	res61: psoriasis	diagnostic	Read
M161200	Psoriasis circinata	res61: psoriasis	diagnostic	Read
M161300	Psoriasis diffusa	res61: psoriasis	diagnostic	Read
M161400	Psoriasis discoidea	res61: psoriasis	diagnostic	Read
M161500	Psoriasis geographica	res61: psoriasis	diagnostic	Read
M161600	Guttate psoriasis	res61: psoriasis	diagnostic	Read
M161700	Psoriasis gyrata	res61: psoriasis	diagnostic	Read
M161800	Psoriasis inveterata	res61: psoriasis	diagnostic	Read
M161900	Psoriasis ostracea	res61: psoriasis	diagnostic	Read
M161A00	Psoriasis palmaris	res61: psoriasis	diagnostic	Read
M161B00	Psoriasis plantaris	res61: psoriasis	diagnostic	Read
M161C00	Psoriasis punctata	res61: psoriasis	diagnostic	Read
M161E00	Psoriasis universalis	res61: psoriasis	diagnostic	Read
M161F00	Psoriasis vulgaris	res61: psoriasis	diagnostic	Read
M161F11	Chronic large plaque psoriasis	res61: psoriasis	diagnostic	Read
M161H00	Erythrodermic psoriasis	res61: psoriasis	diagnostic	Read
M161z00	Psoriasis NOS	res61: psoriasis	diagnostic	Read
M16y.00	Other psoriasis and similar disorders	res61: psoriasis	diagnostic	Read
M16y000	Scalp psoriasis	res61: psoriasis	diagnostic	Read
M16z.00	Psoriasis and similar disorders NOS	res61: psoriasis	diagnostic	Read
Myu3000	[X]Other psoriasis	res61: psoriasis	diagnostic	Read

API

To Export Phenotype Details:

Format	API
XML	site_root/api/v1/public/phenotypes/PH911/version/1901/detail/?format=xml
JSON	site_root/api/v1/public/phenotypes/PH911/version/1901/detail/?format=json
R Package	`# Download here library(ConceptLibraryClient) # Connect to API client = connect_to_API(public=TRUE) # Get details of phenotype details = get_phenotype_detail_by_version('PH911', '1901', api_client=client)`

To Export Phenotype Code List:

Format	API
XML	site_root/api/v1/public/phenotypes/PH911/version/1901/export/codes/?format=xml
JSON	site_root/api/v1/public/phenotypes/PH911/version/1901/export/codes/?format=json
CSV	site_root/phenotypes/PH911/version/1901/export/codes/
R Package	`# Download here library(ConceptLibraryClient) # Connect to API client = connect_to_API(public=TRUE) # Get codelists of phenotype codelists = get_phenotype_code_list('PH911', '1901', api_client=client)`

Version History

Version ID	Name	Owner	Publish date
1901	Psoriasis	ieuan.scanlon	2022-04-04	currently shown