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Psoriasis

Rosa Parisi, Roger T. Webb, Mathew J. Carr, Kieran J. Moriarty, Elise Kleyn, Christopher E. M. Griffiths, Darren M. Ashcroft

Type
Disease or Syndrome
ID
PH911
Version ID
1901
Data Sources
Valid event data range
01/01/1998 - 03/03/2014
Sex
Female, Male
Agreement Date
2017-09-15
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

IMPORTANCE:

People diagnosed with psoriasis have an increased risk of premature mortality, but the underlying reasons for this mortality gap are unclear.

OBJECTIVE:

To investigate whether patients with psoriasis have an elevated risk of alcohol-related mortality.

DESIGN, SETTING, AND PARTICIPANTS:

An incident cohort of patients with psoriasis aged 18 years and older was delineated for 1998 through 2014 using the Clinical Practice Research atalink (CPRD) and linked to Hospital Episode Statistics (HES) and Office for National tatistics (ONS) mortality records. Patients with psoriasis were matched with up to 20 comparison patients without psoriasis on age, sex, and general practice.

MAIN OUTCOMES AND MEASURES:

Alcohol-related deathswere ascertained via the Office for National Statistics mortality records. A stratified Cox proportional hazard model was used to estimate the cause-specific hazard ratio for alcohol-related death, with adjustment for socioeconomic status.

RESULTS:

The cohort included 55 537 with psoriasis and 854 314 patients without psoriasis. Median (interquartile) age at index date was 47 (27) years; 408 230 of total patients (44.9%) were men. During a median (IQR) of 4.4 (6.2) years of follow-up, the alcohol-related mortality rate was 4.8 per 10 000 person-years (95%CI, 4.1-5.6; n = 152) for the psoriasis cohort, vs 2.5 per 10 000 (95%CI, 2.4- 2.7; n = 1118) for the comparison cohort. The hazard ratio for alcohol-related death in patients with psoriasis was 1.58 (95%CI, 1.31-1.91), and the predominant causes of alcohol-related deaths were alcoholic liver disease (65.1%), fibrosis and cirrhosis of the liver (23.7%), and mental and behavioral disorders due to alcohol (7.9%).

CONCLUSIONS AND RELEVANCE:

People with psoriasis have approximately a 60%greater risk of dying due to alcohol-related causes compared with peers of the same age and sex in the general population. This appears to be a key contributor to the premature mortality gap. These findings call for routine screening, identification and treatment, using the Alcohol Use Disorders Identification Test (AUDIT-C) in both primary and secondary care to detect alcohol consumption and misuse among people diagnosed with psoriasis.

Publications

  • Rosa Parisi, Roger T. Webb, Mathew J. Carr, Kieran J. Moriarty, Elise Kleyn, Christopher E. M. Griffiths, Darren M. Ashcroft, Alcohol-Related Mortality in Patients With Psoriasis A Population-Based Cohort Study. JAMA Dermatology, 153(12):1256-1262, 2017.

Clinical Code List

Rows: 24
Code Description Entity type Category Coding System (Read)
M16..00 Psoriasis and similar disorders res61: psoriasis diagnostic Read
M161.00 Other psoriasis res61: psoriasis diagnostic Read
M161000 Psoriasis unspecified res61: psoriasis diagnostic Read
M161100 Psoriasis annularis res61: psoriasis diagnostic Read
M161200 Psoriasis circinata res61: psoriasis diagnostic Read
M161300 Psoriasis diffusa res61: psoriasis diagnostic Read
M161400 Psoriasis discoidea res61: psoriasis diagnostic Read
M161500 Psoriasis geographica res61: psoriasis diagnostic Read
M161600 Guttate psoriasis res61: psoriasis diagnostic Read
M161700 Psoriasis gyrata res61: psoriasis diagnostic Read
M161800 Psoriasis inveterata res61: psoriasis diagnostic Read
M161900 Psoriasis ostracea res61: psoriasis diagnostic Read
M161A00 Psoriasis palmaris res61: psoriasis diagnostic Read
M161B00 Psoriasis plantaris res61: psoriasis diagnostic Read
M161C00 Psoriasis punctata res61: psoriasis diagnostic Read
M161E00 Psoriasis universalis res61: psoriasis diagnostic Read
M161F00 Psoriasis vulgaris res61: psoriasis diagnostic Read
M161F11 Chronic large plaque psoriasis res61: psoriasis diagnostic Read
M161H00 Erythrodermic psoriasis res61: psoriasis diagnostic Read
M161z00 Psoriasis NOS res61: psoriasis diagnostic Read
M16y.00 Other psoriasis and similar disorders res61: psoriasis diagnostic Read
M16y000 Scalp psoriasis res61: psoriasis diagnostic Read
M16z.00 Psoriasis and similar disorders NOS res61: psoriasis diagnostic Read
Myu3000 [X]Other psoriasis res61: psoriasis diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH911/version/1901/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH911/version/1901/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH911', '1901', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH911/version/1901/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH911/version/1901/export/codes/?format=json
CSV site_root/phenotypes/PH911/version/1901/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH911', '1901', api_client=client)

Version History

Version
ID
Name Owner Publish date
1901 Psoriasis ieuan.scanlon 2022-04-04 currently shown

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