The association between psoriasis and risk of major cardiovascular (CV) events (myocardial infarction, acute coronary syndrome, unstable angina, and stroke) is unclear. A cohort study with 48,523 patients with psoriasis and 208,187 controls was conducted. During a median follow-up of 5.2 years, 1,257 patients with psoriasis (2.59%) had a major CV event, compared with 4,784 controls (2.30%). In the multivariable analysis, inflammatory arthritis hazard ratio (HR) 1.36 (1.18–1.58), diabetes HR 1.18 (1.06–1.31), chronic kidney disease HR 1.18 (1.07–1.31), hypertension HR 1.37 (1.29–1.45), transient ischemic attack HR 2.74 (2.41–3.12), atrial fibrillation HR 1.54 (1.36–1.73), valvular heart disease HR 1.23 (1.05–1.44), thromboembolism 1.32 (1.17–1.49), congestive heart failure HR 1.57 (1.39–1.78), depression HR 1.16 (1.01–1.34), current smoker HR 2.18 (2.03–2.33), age (year) HR 1.07 (1.07–1.07), and male gender HR 1.83 (1.69–1.98) were statistically significant for the risk of major CV events. The age- and genderadjusted HRs of a major CV event for psoriasis were 1.10 (1.04–1.17) and for severe psoriasis 1.40 (1.07–1.84), whereas the fully adjusted HRs were attenuated to 1.02 (0.95–1.08) and 1.28 (0.96–1.69). In conclusion, neither psoriasis nor severe psoriasis were associated with the short-to-medium term (over 3–5 years) risk of major CV events after adjusting for known cardiovascular disease risk factors.
Rosa Parisi, Martin K Rutter, Mark Lunt, Helen S Young, Deborah P M Symmons, Christopher E M Griffiths, Darren M. Ashcroft, Psoriasis and the Risk of Major Cardiovascular Events Cohort Study Using the Clinical Practice Research Datalink. Journal of Investigative Dermatology, 135, 2015.
Code | Description | Entity type | Category | Coding System (Read) |
---|---|---|---|---|
M16..00 | Psoriasis and similar disorders | res66: psoriasis | diagnostic | Read |
M161.00 | Other psoriasis | res66: psoriasis | diagnostic | Read |
M161000 | Psoriasis unspecified | res66: psoriasis | diagnostic | Read |
M161100 | Psoriasis annularis | res66: psoriasis | diagnostic | Read |
M161200 | Psoriasis circinata | res66: psoriasis | diagnostic | Read |
M161300 | Psoriasis diffusa | res66: psoriasis | diagnostic | Read |
M161400 | Psoriasis discoidea | res66: psoriasis | diagnostic | Read |
M161500 | Psoriasis geographica | res66: psoriasis | diagnostic | Read |
M161600 | Guttate psoriasis | res66: psoriasis | diagnostic | Read |
M161700 | Psoriasis gyrata | res66: psoriasis | diagnostic | Read |
M161800 | Psoriasis inveterata | res66: psoriasis | diagnostic | Read |
M161900 | Psoriasis ostracea | res66: psoriasis | diagnostic | Read |
M161A00 | Psoriasis palmaris | res66: psoriasis | diagnostic | Read |
M161B00 | Psoriasis plantaris | res66: psoriasis | diagnostic | Read |
M161C00 | Psoriasis punctata | res66: psoriasis | diagnostic | Read |
M161E00 | Psoriasis universalis | res66: psoriasis | diagnostic | Read |
M161F00 | Psoriasis vulgaris | res66: psoriasis | diagnostic | Read |
M161F11 | Chronic large plaque psoriasis | res66: psoriasis | diagnostic | Read |
M161H00 | Erythrodermic psoriasis | res66: psoriasis | diagnostic | Read |
M161z00 | Psoriasis NOS | res66: psoriasis | diagnostic | Read |
M16y.00 | Other psoriasis and similar disorders | res66: psoriasis | diagnostic | Read |
M16y000 | Scalp psoriasis | res66: psoriasis | diagnostic | Read |
M16z.00 | Psoriasis and similar disorders NOS | res66: psoriasis | diagnostic | Read |
Myu3000 | [X]Other psoriasis | res66: psoriasis | diagnostic | Read |
To Export Phenotype Details:
Format | API |
---|---|
XML | site_root/api/v1/public/phenotypes/PH912/version/1903/detail/?format=xml |
JSON | site_root/api/v1/public/phenotypes/PH912/version/1903/detail/?format=json |
R Package |
|
To Export Phenotype Code List:
Format | API |
---|---|
XML | site_root/api/v1/public/phenotypes/PH912/version/1903/export/codes/?format=xml |
JSON | site_root/api/v1/public/phenotypes/PH912/version/1903/export/codes/?format=json |
CSV | site_root/phenotypes/PH912/version/1903/export/codes/ |
R Package |
|
Version ID |
Name | Owner | Publish date | |
---|---|---|---|---|
1903 | Psoriasis | ieuan.scanlon | 2022-04-04 | currently shown |
Export - export all codes into a csv file/JSON/XML for the current phenotype version.
Print - Print page.