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Chronic Kidney Disease (CKD)

Alison K Wright, Evangelos Kontopantelis, Richard Emsley, Ian Buchan, Mamas A Mamas, Naveed Sattar, Darren M Ashcroft, Martin M Rutter

Type
Disease or Syndrome
ID
PH920
Version ID
1919
Data Sources
Valid event data range
01/01/2006 - 31/12/2013
Sex
Female, Male
Agreement Date
2019-06-11
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

BACKGROUND:

With recent changes in the United Kingdom’s clinical practice for diabetes mellitus care, contemporary estimates of sex disparities in cardiovascular risk and risk factor management are needed.

METHODS:

In this retrospective cohort study, using the Clinical Practice Research Datalink linked to hospital and death records for people in England, we identified 79 985 patients with incident type 2 diabetes mellitus (T2DM) between 2006 to 2013 matched to 386 547 patients without diabetes mellitus. Sex-stratified Cox models were used to assess cardiovascular risk.

RESULTS:

Compared with women without T2DM, women with T2DM had a higher cardiovascular event risk (adjusted hazard ratio, 1.20 [95% confidence interval, 1.12–1.28]) with similar corresponding data in men (hazard ratio, 1.12 [1.06–1.19]), leading to a nonsignificant higher relative risk in women (risk ratio, 1.07 [0.98–1.17]). However, some important sex differences in the management of risk factors were observed. Compared with men with T2DM, women with T2DM were more likely to be obese, hypertensive, and have hypercholesterolemia, but were less likely to be prescribed lipid-lowering medication and angiotensin-converting enzyme inhibitors, especially if they had cardiovascular disease.

CONCLUSIONS:

Compared with men developing T2DM, women with T2DM do not have a significantly higher relative increase in cardiovascular risk, but ongoing sex disparities in prescribing should prompt heightened efforts to improve the standard and equity of diabetes mellitus care in women and men.

Publications

  • Alison K Wright,Evangelos Kontopantelis, Richard Emsley, Ian Buchan, Mamas A Mamas, Naveed Sattar, Darren M Ashcroft, Martin K Rutter, , Cardiovascular Risk and Risk Factor Management in Type 2 Diabetes Mellitus A Population-Based Cohort Study Assessing Sex Disparities. Circulation, 139:2742-2753, 2019.

Clinical Code List

Rows: 58
Code Description Entity type Category Coding System (Read)
1Z10.00 Chronic kidney disease stage 1 res72: CKD diagnostic Read
1Z11.00 Chronic kidney disease stage 2 res72: CKD diagnostic Read
1Z12.00 Chronic kidney disease stage 3 res72: CKD diagnostic Read
1Z13.00 Chronic kidney disease stage 4 res72: CKD diagnostic Read
1Z14.00 Chronic kidney disease stage 5 res72: CKD diagnostic Read
1Z15.00 Chronic kidney disease stage 3A res72: CKD diagnostic Read
1Z16.00 Chronic kidney disease stage 3B res72: CKD diagnostic Read
1Z17.00 Chronic kidney disease stage 1 with proteinuria res72: CKD diagnostic Read
1Z17.11 CKD stage 1 with proteinuria res72: CKD diagnostic Read
1Z18.00 Chronic kidney disease stage 1 without proteinuria res72: CKD diagnostic Read
1Z18.11 CKD stage 1 without proteinuria res72: CKD diagnostic Read
1Z19.00 Chronic kidney disease stage 2 with proteinuria res72: CKD diagnostic Read
1Z19.11 CKD stage 2 with proteinuria res72: CKD diagnostic Read
1Z1A.00 Chronic kidney disease stage 2 without proteinuria res72: CKD diagnostic Read
1Z1A.11 CKD stage 2 without proteinuria res72: CKD diagnostic Read
1Z1B.00 Chronic kidney disease stage 3 with proteinuria res72: CKD diagnostic Read
1Z1B.11 CKD stage 3 with proteinuria res72: CKD diagnostic Read
1Z1C.00 Chronic kidney disease stage 3 without proteinuria res72: CKD diagnostic Read
1Z1C.11 CKD stage 3 without proteinuria res72: CKD diagnostic Read
1Z1D.00 Chronic kidney disease stage 3A with proteinuria res72: CKD diagnostic Read
1Z1D.11 CKD stage 3A with proteinuria res72: CKD diagnostic Read
1Z1E.00 Chronic kidney disease stage 3A without proteinuria res72: CKD diagnostic Read
1Z1E.11 CKD stage 3A without proteinuria res72: CKD diagnostic Read
1Z1F.00 Chronic kidney disease stage 3B with proteinuria res72: CKD diagnostic Read
1Z1F.11 CKD stage 3B with proteinuria res72: CKD diagnostic Read
1Z1G.00 Chronic kidney disease stage 3B without proteinuria res72: CKD diagnostic Read
1Z1G.11 CKD stage 3B without proteinuria res72: CKD diagnostic Read
1Z1H.00 Chronic kidney disease stage 4 with proteinuria res72: CKD diagnostic Read
1Z1H.11 CKD stage 4 with proteinuria res72: CKD diagnostic Read
1Z1J.00 Chronic kidney disease stage 4 without proteinuria res72: CKD diagnostic Read
1Z1J.11 CKD stage 4 without proteinuria res72: CKD diagnostic Read
1Z1K.00 Chronic kidney disease stage 5 with proteinuria res72: CKD diagnostic Read
1Z1K.11 CKD stage 5 with proteinuria res72: CKD diagnostic Read
1Z1L.00 Chronic kidney disease stage 5 without proteinuria res72: CKD diagnostic Read
1Z1L.11 CKD stage 5 without proteinuria res72: CKD diagnostic Read
1Z1M.00 CKD with GFR category G1 & albuminuria category A1 res72: CKD diagnostic Read
1Z1N.00 CKD with GFR category G1 & albuminuria category A2 res72: CKD diagnostic Read
1Z1P.00 CKD with GFR category G1 & albuminuria category A3 res72: CKD diagnostic Read
1Z1Q.00 CKD with GFR category G2 & albuminuria category A1 res72: CKD diagnostic Read
1Z1R.00 CKD with GFR category G2 & albuminuria category A2 res72: CKD diagnostic Read
1Z1S.00 CKD with GFR category G2 & albuminuria category A3 res72: CKD diagnostic Read
1Z1T.00 CKD with GFR category G3a & albuminuria category A1 res72: CKD diagnostic Read
1Z1V.00 CKD with GFR category G3a & albuminuria category A2 res72: CKD diagnostic Read
1Z1W.00 CKD with GFR category G3a & albuminuria category A3 res72: CKD diagnostic Read
1Z1X.00 CKD with GFR category G3b & albuminuria category A1 res72: CKD diagnostic Read
1Z1Y.00 CKD with GFR category G3b & albuminuria category A2 res72: CKD diagnostic Read
1Z1Z.00 CKD with GFR category G3b & albuminuria category A3 res72: CKD diagnostic Read
1Z1a.00 CKD with GFR category G4 & albuminuria category A1 res72: CKD diagnostic Read
1Z1b.00 CKD with GFR category G4 & albuminuria category A2 res72: CKD diagnostic Read
1Z1c.00 CKD with GFR category G4 & albuminuria category A3 res72: CKD diagnostic Read
1Z1d.00 CKD with GFR category G5 & albuminuria category A1 res72: CKD diagnostic Read
1Z1e.00 CKD with GFR category G5 & albuminuria category A2 res72: CKD diagnostic Read
1Z1f.00 CKD with GFR category G5 & albuminuria category A3 res72: CKD diagnostic Read
K051.00 Chronic kidney disease stage 1 res72: CKD diagnostic Read
K052.00 Chronic kidney disease stage 2 res72: CKD diagnostic Read
K053.00 Chronic kidney disease stage 3 res72: CKD diagnostic Read
K054.00 Chronic kidney disease stage 4 res72: CKD diagnostic Read
K055.00 Chronic kidney disease stage 5 res72: CKD diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH920/version/1919/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH920/version/1919/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH920', '1919', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH920/version/1919/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH920/version/1919/export/codes/?format=json
CSV site_root/phenotypes/PH920/version/1919/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH920', '1919', api_client=client)

Version History

Version
ID
Name Owner Publish date
1919 Chronic Kidney Disease (CKD) ieuan.scanlon 2022-04-04 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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