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Microvascular Complications

Alison K Wright, Evangelos Kontopantelis, Richard Emsley, Ian Buchan, Mamas A Mamas, Naveed Sattar, Darren M Ashcroft, Martin M Rutter

Type
Disease or Syndrome
ID
PH928
Version ID
1935
Data Sources
Valid event data range
01/01/2006 - 31/12/2013
Sex
Female, Male
Agreement Date
2019-06-11
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

BACKGROUND:

With recent changes in the United Kingdom’s clinical practice for diabetes mellitus care, contemporary estimates of sex disparities in cardiovascular risk and risk factor management are needed.

METHODS:

In this retrospective cohort study, using the Clinical Practice Research Datalink linked to hospital and death records for people in England, we identified 79 985 patients with incident type 2 diabetes mellitus (T2DM) between 2006 to 2013 matched to 386 547 patients without diabetes mellitus. Sex-stratified Cox models were used to assess cardiovascular risk.

RESULTS:

Compared with women without T2DM, women with T2DM had a higher cardiovascular event risk (adjusted hazard ratio, 1.20 [95% confidence interval, 1.12–1.28]) with similar corresponding data in men (hazard ratio, 1.12 [1.06–1.19]), leading to a nonsignificant higher relative risk in women (risk ratio, 1.07 [0.98–1.17]). However, some important sex differences in the management of risk factors were observed. Compared with men with T2DM, women with T2DM were more likely to be obese, hypertensive, and have hypercholesterolemia, but were less likely to be prescribed lipid-lowering medication and angiotensin-converting enzyme inhibitors, especially if they had cardiovascular disease.

CONCLUSIONS:

Compared with men developing T2DM, women with T2DM do not have a significantly higher relative increase in cardiovascular risk, but ongoing sex disparities in prescribing should prompt heightened efforts to improve the standard and equity of diabetes mellitus care in women and men.

Publications

  • Alison K Wright,Evangelos Kontopantelis, Richard Emsley, Ian Buchan, Mamas A Mamas, Naveed Sattar, Darren M Ashcroft, Martin K Rutter, , Cardiovascular Risk and Risk Factor Management in Type 2 Diabetes Mellitus A Population-Based Cohort Study Assessing Sex Disparities. Circulation, 139:2742-2753, 2019.

Clinical Code List

Rows: 62
Code Description Entity type Category Coding System (Read)
2BBP.00 O/E - right eye background diabetic retinopathy res72: Microvascular complications diagnostic Read
2BBQ.00 O/E - left eye background diabetic retinopathy res72: Microvascular complications diagnostic Read
2BBR.00 O/E - right eye preproliferative diabetic retinopathy res72: Microvascular complications diagnostic Read
2BBS.00 O/E - left eye preproliferative diabetic retinopathy res72: Microvascular complications diagnostic Read
2BBT.00 O/E - right eye proliferative diabetic retinopathy res72: Microvascular complications diagnostic Read
2BBV.00 O/E - left eye proliferative diabetic retinopathy res72: Microvascular complications diagnostic Read
2BBY.00 O/E - referable retinopathy res72: Microvascular complications diagnostic Read
2BBa.00 O/E- non-referable retinopathy res72: Microvascular complications diagnostic Read
2BBk.00 O/E - right eye stable treated prolif diabetic retinopathy res72: Microvascular complications diagnostic Read
2BBl.00 O/E - left eye stable treated prolif diabetic retinopathy res72: Microvascular complications diagnostic Read
2BBo.00 O/E - sight threatening diabetic retinopathy res72: Microvascular complications diagnostic Read
2BBr.00 Impaired vision due to diabetic retinopathy res72: Microvascular complications diagnostic Read
C106.12 Diabetes mellitus with neuropathy res72: Microvascular complications diagnostic Read
C106.13 Diabetes mellitus with polyneuropathy res72: Microvascular complications diagnostic Read
C108700 Insulin dependent diabetes mellitus with retinopathy res72: Microvascular complications diagnostic Read
C108711 Type I diabetes mellitus with retinopathy res72: Microvascular complications diagnostic Read
C108712 Type 1 diabetes mellitus with retinopathy res72: Microvascular complications diagnostic Read
C108B00 Insulin dependent diabetes mellitus with mononeuropathy res72: Microvascular complications diagnostic Read
C108B11 Type I diabetes mellitus with mononeuropathy res72: Microvascular complications diagnostic Read
C108C00 Insulin dependent diabetes mellitus with polyneuropathy res72: Microvascular complications diagnostic Read
C109600 Non-insulin-dependent diabetes mellitus with retinopathy res72: Microvascular complications diagnostic Read
C109611 Type II diabetes mellitus with retinopathy res72: Microvascular complications diagnostic Read
C109612 Type 2 diabetes mellitus with retinopathy res72: Microvascular complications diagnostic Read
C109A00 Non-insulin dependent diabetes mellitus with mononeuropathy res72: Microvascular complications diagnostic Read
C109A11 Type II diabetes mellitus with mononeuropathy res72: Microvascular complications diagnostic Read
C109B00 Non-insulin dependent diabetes mellitus with polyneuropathy res72: Microvascular complications diagnostic Read
C109B11 Type II diabetes mellitus with polyneuropathy res72: Microvascular complications diagnostic Read
C109B12 Type 2 diabetes mellitus with polyneuropathy res72: Microvascular complications diagnostic Read
C10E700 Type 1 diabetes mellitus with retinopathy res72: Microvascular complications diagnostic Read
C10E711 Type I diabetes mellitus with retinopathy res72: Microvascular complications diagnostic Read
C10E712 Insulin dependent diabetes mellitus with retinopathy res72: Microvascular complications diagnostic Read
C10EB00 Type 1 diabetes mellitus with mononeuropathy res72: Microvascular complications diagnostic Read
C10EC00 Type 1 diabetes mellitus with polyneuropathy res72: Microvascular complications diagnostic Read
C10EC11 Type I diabetes mellitus with polyneuropathy res72: Microvascular complications diagnostic Read
C10EC12 Insulin dependent diabetes mellitus with polyneuropathy res72: Microvascular complications diagnostic Read
C10F600 Type 2 diabetes mellitus with retinopathy res72: Microvascular complications diagnostic Read
C10F611 Type II diabetes mellitus with retinopathy res72: Microvascular complications diagnostic Read
C10FA00 Type 2 diabetes mellitus with mononeuropathy res72: Microvascular complications diagnostic Read
C10FA11 Type II diabetes mellitus with mononeuropathy res72: Microvascular complications diagnostic Read
C10FB00 Type 2 diabetes mellitus with polyneuropathy res72: Microvascular complications diagnostic Read
C10FB11 Type II diabetes mellitus with polyneuropathy res72: Microvascular complications diagnostic Read
F171.00 Peripheral autonomic neuropathy disease EC res72: Microvascular complications diagnostic Read
F171100 Autonomic neuropathy due to diabetes res72: Microvascular complications diagnostic Read
F366.00 Polyneuropathy res72: Microvascular complications diagnostic Read
F367.00 Peripheral neuropathy res72: Microvascular complications diagnostic Read
F372.00 Polyneuropathy in diabetes res72: Microvascular complications diagnostic Read
F372.11 Diabetic polyneuropathy res72: Microvascular complications diagnostic Read
F372.12 Diabetic neuropathy res72: Microvascular complications diagnostic Read
F372000 Acute painful diabetic neuropathy res72: Microvascular complications diagnostic Read
F372100 Chronic painful diabetic neuropathy res72: Microvascular complications diagnostic Read
F372200 Asymptomatic diabetic neuropathy res72: Microvascular complications diagnostic Read
F374500 Polyneuropathy in hypoglycaemia res72: Microvascular complications diagnostic Read
F3y0.00 Diabetic mononeuropathy res72: Microvascular complications diagnostic Read
F420.00 Diabetic retinopathy res72: Microvascular complications diagnostic Read
F420000 Background diabetic retinopathy res72: Microvascular complications diagnostic Read
F420100 Proliferative diabetic retinopathy res72: Microvascular complications diagnostic Read
F420200 Preproliferative diabetic retinopathy res72: Microvascular complications diagnostic Read
F420600 Non proliferative diabetic retinopathy res72: Microvascular complications diagnostic Read
F420700 High risk proliferative diabetic retinopathy res72: Microvascular complications diagnostic Read
F420800 High risk non proliferative diabetic retinopathy res72: Microvascular complications diagnostic Read
F420z00 Diabetic retinopathy NOS res72: Microvascular complications diagnostic Read
F422z00 Proliferative retinopathy NOS res72: Microvascular complications diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH928/version/1935/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH928/version/1935/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH928', '1935', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH928/version/1935/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH928/version/1935/export/codes/?format=json
CSV site_root/phenotypes/PH928/version/1935/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH928', '1935', api_client=client)

Version History

Version
ID
Name Owner Publish date
1935 Microvascular Complications ieuan.scanlon 2022-04-04 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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