Phenotype Library | phenotype: Obesity

Obesity

Alison K Wright, Evangelos Kontopantelis, Richard Emsley, Ian Buchan, Mamas A Mamas, Naveed Sattar, Darren M Ashcroft, Martin M Rutter

PH929

Version ID

1937

Type

Disease or Syndrome

Data Sources

CPRD GOLD

Valid event data range

01/01/2006 - 31/12/2013

Sex

♀ Female ♂ Male

Agreement Date

2019-06-11

Coding system

Read codes v2

Collections

ClinicalCodes Repository Phenotype Library

Definition

BACKGROUND:

With recent changes in the United Kingdom’s clinical practice for diabetes mellitus care, contemporary estimates of sex disparities in cardiovascular risk and risk factor management are needed.

METHODS:

In this retrospective cohort study, using the Clinical Practice Research Datalink linked to hospital and death records for people in England, we identified 79 985 patients with incident type 2 diabetes mellitus (T2DM) between 2006 to 2013 matched to 386 547 patients without diabetes mellitus. Sex-stratified Cox models were used to assess cardiovascular risk.

RESULTS:

Compared with women without T2DM, women with T2DM had a higher cardiovascular event risk (adjusted hazard ratio, 1.20 [95% confidence interval, 1.12–1.28]) with similar corresponding data in men (hazard ratio, 1.12 [1.06–1.19]), leading to a nonsignificant higher relative risk in women (risk ratio, 1.07 [0.98–1.17]). However, some important sex differences in the management of risk factors were observed. Compared with men with T2DM, women with T2DM were more likely to be obese, hypertensive, and have hypercholesterolemia, but were less likely to be prescribed lipid-lowering medication and angiotensin-converting enzyme inhibitors, especially if they had cardiovascular disease.

CONCLUSIONS:

Compared with men developing T2DM, women with T2DM do not have a significantly higher relative increase in cardiovascular risk, but ongoing sex disparities in prescribing should prompt heightened efforts to improve the standard and equity of diabetes mellitus care in women and men.

Publications

Alison K Wright,Evangelos Kontopantelis, Richard Emsley, Ian Buchan, Mamas A Mamas, Naveed Sattar, Darren M Ashcroft, Martin K Rutter, , Cardiovascular Risk and Risk Factor Management in Type 2 Diabetes Mellitus A Population-Based Cohort Study Assessing Sex Disparities. Circulation, 139:2742-2753, 2019.

Clinical Code List

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C2705/6823 Obesity - Primary Care - Read codes v2

Rows: 21

Code	Description	Entity type	Category	Coding System (Read)
22A5.11	O/E - obese	res72: Obesity	diagnostic	Read
22K5.00	Body mass index 30+ - obesity	res72: Obesity	diagnostic	Read
22K7.00	Body mass index 40+ - severely obese	res72: Obesity	diagnostic	Read
22KC.00	Obese class I (body mass index 30.0 - 34.9)	res72: Obesity	diagnostic	Read
22KD.00	Obese class II (body mass index 35.0 - 39.9)	res72: Obesity	diagnostic	Read
22KE.00	Obese class III (BMI equal to or greater than 40.0)	res72: Obesity	diagnostic	Read
66C4.00	Has seen dietician - obesity	res72: Obesity	diagnostic	Read
66C5.00	Treatment of obesity changed	res72: Obesity	diagnostic	Read
66C6.00	Treatment of obesity started	res72: Obesity	diagnostic	Read
8CV7.00	Anti-obesity drug therapy commenced	res72: Obesity	diagnostic	Read
C38..00	Obesity and other hyperalimentation	res72: Obesity	diagnostic	Read
C380.00	Obesity	res72: Obesity	diagnostic	Read
C380200	Extreme obesity with alveolar hypoventilation	res72: Obesity	diagnostic	Read
C380300	Morbid obesity	res72: Obesity	diagnostic	Read
C380400	Central obesity	res72: Obesity	diagnostic	Read
C380500	Generalised obesity	res72: Obesity	diagnostic	Read
C38y011	Obesity hypoventilation syndrome	res72: Obesity	diagnostic	Read
C38z000	Simple obesity NOS	res72: Obesity	diagnostic	Read
Cyu7.00	[X]Obesity and other hyperalimentation	res72: Obesity	diagnostic	Read
Cyu7000	[X]Other obesity	res72: Obesity	diagnostic	Read
ZC2CM00	Dietary advice for obesity	res72: Obesity	diagnostic	Read

API

To Export Phenotype Details:

Format	API
XML	site_root/api/v1/public/phenotypes/PH929/version/1937/detail/?format=xml
JSON	site_root/api/v1/public/phenotypes/PH929/version/1937/detail/?format=json
R Package	`# Download here library(ConceptLibraryClient) # Connect to API client = connect_to_API(public=TRUE) # Get details of phenotype details = get_phenotype_detail_by_version('PH929', '1937', api_client=client)`

To Export Phenotype Code List:

Format	API
XML	site_root/api/v1/public/phenotypes/PH929/version/1937/export/codes/?format=xml
JSON	site_root/api/v1/public/phenotypes/PH929/version/1937/export/codes/?format=json
CSV	site_root/phenotypes/PH929/version/1937/export/codes/
R Package	`# Download here library(ConceptLibraryClient) # Connect to API client = connect_to_API(public=TRUE) # Get codelists of phenotype codelists = get_phenotype_code_list('PH929', '1937', api_client=client)`

Version History

Version ID	Name	Owner	Publish date
1937	Obesity	ieuan.scanlon	2022-04-04	currently shown