Phenotype Library | phenotype: Agranulocytosis

Agranulocytosis

Kuan V, Denaxas S, Gonzalez-Izquierdo A, Direk K, Bhatti O, Husain S, Sutaria S, Hingorani M, Nitsch D, Parisinos C, Lumbers T, Mathur R, Sofat R, Casas JP, Wong I, Hemingway H, Hingorani A

PH93

Version ID

186

Type

Disease or Syndrome

Data Sources

CPRD GOLD , HES Admitted Patient Care data for CPRD GOLD

Valid event data range

01/01/1999 - 01/07/2016

Sex

♀ Female ♂ Male

Agreement Date

2019-05-20

Coding system

Read codes v2 ICD10 codes Med codes

Collections

CALIBER Phenotype Library

Definition

At the specified date, a patient is defined as having had 'Agranulocytosis' IF they meet the criteria for any of the following on or before the specified date. The earliest date on which the individual meets any of the following criteria on or before the specified date is defined as the first event date:

Primary care

'Agranulocytosis' diagnosis or history of diagnosis during a consultation

OR Secondary care (ICD10)

ALL diagnoses of 'Agranulocytosis' or history of diagnosis during a hospitalization

Implementation

PhenoFlow Implementation:

https://kclhi.org/phenoflow/phenotype/download/275

Publications

Kuan V., Denaxas S., Gonzalez-Izquierdo A. et al. A chronological map of 308 physical and mental health conditions from 4 million individuals in the National Health Service. The Lancet Digital Health - DOI 10.1016/S2589-7500(19)30012-3

Clinical Code List

CSV

JSON

XML

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C942/3023 Agranulocytosis - Primary care - Read codes v2

Rows: 22

Code	Description	Disease	Medcode	Category
42H2.00	Leucopenia - low white count	Agranulocytosis	26325.0	Diagnosis of Agranulocytosis
42H2.11	Leucopenia	Agranulocytosis	1955.0	Diagnosis of Agranulocytosis
42H4.00	Agranulocytosis	Agranulocytosis	21258.0	Diagnosis of Agranulocytosis
42J2.00	Neutropenia	Agranulocytosis	4463.0	Diagnosis of Agranulocytosis
D400.00	Agranulocytosis	Agranulocytosis	4818.0	Diagnosis of Agranulocytosis
D400.11	Kostmann's syndrome	Agranulocytosis	70337.0	Diagnosis of Agranulocytosis
D400.12	Neutropenia	Agranulocytosis	2071.0	Diagnosis of Agranulocytosis
D400000	Idiopathic agranulocytosis	Agranulocytosis	63204.0	Diagnosis of Agranulocytosis
D400011	Idiopathic neutropenia	Agranulocytosis	18054.0	Diagnosis of Agranulocytosis
D400100	Primary splenic neutropenia	Agranulocytosis	96380.0	Diagnosis of Agranulocytosis
D400200	Agranulocytosis - drug induced	Agranulocytosis	54000.0	Diagnosis of Agranulocytosis
D400211	Neutropenia - drug induced	Agranulocytosis	35719.0	Diagnosis of Agranulocytosis
D400312	Neutropenia due to irradiation	Agranulocytosis	40310.0	Diagnosis of Agranulocytosis
D400400	Agranulocytosis due to infection	Agranulocytosis	50375.0	Diagnosis of Agranulocytosis
D400411	Neutropenia due to infection	Agranulocytosis	17705.0	Diagnosis of Agranulocytosis
D400600	Drug-induced neutropenia	Agranulocytosis	30008.0	Diagnosis of Agranulocytosis
D400800	Acquired neutropenia NEC	Agranulocytosis	49346.0	Diagnosis of Agranulocytosis
D400811	Acquired agranulocytosis NEC	Agranulocytosis	65903.0	Diagnosis of Agranulocytosis
D400900	Cyclical neutropenia	Agranulocytosis	32141.0	Diagnosis of Agranulocytosis
D400A00	Leucopenia	Agranulocytosis	3372.0	Diagnosis of Agranulocytosis
D400y00	Other specified agranulocytosis	Agranulocytosis	64300.0	Diagnosis of Agranulocytosis
D400z00	Agranulocytosis NOS	Agranulocytosis	63055.0	Diagnosis of Agranulocytosis

C943/3025 Agranulocytosis - Primary care - Med codes

Rows: 22

Code	Description	Disease	ReadcodeDescr	Readcode
17705.0	Diagnosis of Agranulocytosis	Agranulocytosis	Neutropenia due to infection	D400411
18054.0	Diagnosis of Agranulocytosis	Agranulocytosis	Idiopathic neutropenia	D400011
1955.0	Diagnosis of Agranulocytosis	Agranulocytosis	Leucopenia	42H2.11
2071.0	Diagnosis of Agranulocytosis	Agranulocytosis	Neutropenia	D400.12
21258.0	Diagnosis of Agranulocytosis	Agranulocytosis	Agranulocytosis	42H4.00
26325.0	Diagnosis of Agranulocytosis	Agranulocytosis	Leucopenia - low white count	42H2.00
30008.0	Diagnosis of Agranulocytosis	Agranulocytosis	Drug-induced neutropenia	D400600
32141.0	Diagnosis of Agranulocytosis	Agranulocytosis	Cyclical neutropenia	D400900
3372.0	Diagnosis of Agranulocytosis	Agranulocytosis	Leucopenia	D400A00
35719.0	Diagnosis of Agranulocytosis	Agranulocytosis	Neutropenia - drug induced	D400211
40310.0	Diagnosis of Agranulocytosis	Agranulocytosis	Neutropenia due to irradiation	D400312
4463.0	Diagnosis of Agranulocytosis	Agranulocytosis	Neutropenia	42J2.00
4818.0	Diagnosis of Agranulocytosis	Agranulocytosis	Agranulocytosis	D400.00
49346.0	Diagnosis of Agranulocytosis	Agranulocytosis	Acquired neutropenia NEC	D400800
50375.0	Diagnosis of Agranulocytosis	Agranulocytosis	Agranulocytosis due to infection	D400400
54000.0	Diagnosis of Agranulocytosis	Agranulocytosis	Agranulocytosis - drug induced	D400200
63055.0	Diagnosis of Agranulocytosis	Agranulocytosis	Agranulocytosis NOS	D400z00
63204.0	Diagnosis of Agranulocytosis	Agranulocytosis	Idiopathic agranulocytosis	D400000
64300.0	Diagnosis of Agranulocytosis	Agranulocytosis	Other specified agranulocytosis	D400y00
65903.0	Diagnosis of Agranulocytosis	Agranulocytosis	Acquired agranulocytosis NEC	D400811
70337.0	Diagnosis of Agranulocytosis	Agranulocytosis	Kostmann's syndrome	D400.11
96380.0	Diagnosis of Agranulocytosis	Agranulocytosis	Primary splenic neutropenia	D400100

C944/3027 Agranulocytosis - Secondary care - Diagnoses - ICD10 codes

Rows: 1

Code	Description	Disease	Category
D70	Agranulocytosis	Agranulocytosis	Diagnosis of Agranulocytosis

API

To Export Phenotype Details:

Format	API
XML	site_root/api/v1/public/phenotypes/PH93/version/186/detail/?format=xml
JSON	site_root/api/v1/public/phenotypes/PH93/version/186/detail/?format=json
R Package	`# Download here library(ConceptLibraryClient) # Connect to API client = connect_to_API(public=TRUE) # Get details of phenotype details = get_phenotype_detail_by_version('PH93', '186', api_client=client)`

To Export Phenotype Code List:

Format	API
XML	site_root/api/v1/public/phenotypes/PH93/version/186/export/codes/?format=xml
JSON	site_root/api/v1/public/phenotypes/PH93/version/186/export/codes/?format=json
CSV	site_root/phenotypes/PH93/version/186/export/codes/
R Package	`# Download here library(ConceptLibraryClient) # Connect to API client = connect_to_API(public=TRUE) # Get codelists of phenotype codelists = get_phenotype_code_list('PH93', '186', api_client=client)`

Version History

Version ID	Name	Owner	Publish date
186	Agranulocytosis	ieuan.scanlon	2021-10-06	currently shown