Phenotype Library | phenotype: Bipolar Disorder, Schizophrenia and Other Psychotic Disorders Primary Care

Bipolar Disorder, Schizophrenia and Other Psychotic Disorders Primary Care

John, A, McGregor, J., Jones, I., Lee, S. C., Walters, J. T. R., Owen, M. J., O'Donovan, M., DelPozo-Banos, M., Berridge, D., & Lloyd, K.

PH940

Version ID

1959

Type

Disease or syndrome

Data Sources

GP dataset - Welsh Primary Care

Sex

♀ Female ♂ Male

Agreement Date

2022-04-01

Coding system

Read codes v2

Collections

Adolescent Data Platform (ADP) DATAMIND Phenotype Library

Definition

The attached code lists for bipolar disorder, schizophrenia and other psychotic disorders are based on John et al. (2018) and reviewed by two clinicians (Prof. Keith Lloyd and Prof. Ann John) in the study team. The codes in these lists exclude organic psychoses (e.g., drug and alcohol induced) and psychoses with origins in childhood. In keeping with John et al. (2018), the codes are divided into three categories: 1) schizophrenia-related disorders that include schizophrenia, schizotypal and delusional disorders, 2) bipolar disorder and other mood related disorders that include bipolar disorder, manic depressive episodes with psychotic symptoms, and 3) other psychotic disorders/severe mental illnesses (SMIs). Additional Read codes for 'other psychotic disorders' that were mapped to the ICD-10 codes for acute and transient psychotic disorders (F23), depressive episodes/disorders with psychotic symptoms (F32.3 and F33.3) were added to the list as reviewed by two clinicians (Prof. Keith Lloyd and Prof. Ann John) in the study team. Information on algorithm construction are included in the following papers (Economou et. al. 2012; McGregor et. al. 2010).

Publications

John, A, McGregor, J., Jones, I., Lee, S. C., Walters, J. T. R., Owen, M. J., O'Donovan, M., DelPozo-Banos, M., Berridge, D., & Lloyd, K. (2018). Premature mortality among people with severe mental illness - New evidence from linked primary care data. Schizophrenia Research, 199, 154-162. https://doi.org/10.1016/j.schres.2018.04.009
John, A., Friedmann, Y., Delpozo-Banos, M., Frizzati, A., Ford, T., & Thapar, A. 2022. "Association of School Absence and Exclusion with Recorded Neurodevelopmental Disorders, Mental Disorders, or Self-Harm: A Nationwide, Retrospective, Electronic Cohort Study of Children and Young People in Wales, UK."
Economou, A. Michelle G. McGregor, J. Craddock, N. Lyons, R,A. Owen, M.J. Price, V. Thomson, S. Walters, J.T. & Lloyd, K. (2012). "The Health Informatics Cohort Enhancement Project (HICE): Using Routinely Collected Primary Care Data to Identify People with a Lifetime Diagnosis of Psychotic Disorder." BMC Research Notes 5(1):1-6.
McGregor, J. Brooks, C. Chalasani, P. Chukwuma, J. Hutchings, H. Lyons, R,A. & Lloyd, K. (2010). "The Health Informatics Trial Enhancement Project (HITE): Using Routinely Collected Primary Care Data to Identify Potential Participants for a Depression Trial." Trials 11(1):1-6.
Main reference link: https://www.sciencedirect.com/science/article/pii/S0920996418301981?via%3Dihub

Clinical Code List

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C2714/6844 Bipolar Disorder and Other Mood Related Disorders - Primary Care - Read codes v2

Rows: 80

Code	Description
146D.	h/o: manic depressive disorder
E110.	manic disorder, single episode
E1100	single manic episode-unspecif\| single manic episode, unspecified
E1101	single manic episode-mild\| single manic episode, mild
E1102	single manic episode-moderate\| single manic episode, moderate
E1103	single manic episode-severe\| single manic episode, severe without mention of psychosis
E1104	single manic epis.-severe+psyc\| single manic episode, severe, with psychosis
E1105	single manic epis.-part remiss.\| single manic episode in partial or unspecified remission
E1106	single manic epis.-full remiss.\| single manic episode in full remission
E110z	manic disorder- single epis.nos \| manic disorder, single episode nos
E111.	recurrent manic episodes
E1110	recurrent manic episodes - unspec \| recurrent manic episodes, unspecified
E1111	recurrent manic episodes - mild \| recurrent manic episodes, mild
E1112	recurrent manic epis. - moderate \| recurrent manic episodes, moderate
E1113	recurrent manic epis. - severe \| recurrent manic episodes, severe without mention psychosis
E1114	recurr. manic epis. - severe+psyc \| recurrent manic episodes, severe, with psychosis
E1115	recur.manic spis. - part remiss \| recurrent manic episodes, partial or unspecified remission \| recurrent manic episodes, in partial or unspecified remission
E1116	recur.manic spis. - full remiss \| recurrent manic episodes, in full remission
E111z	recurrent manic episode nos
E114.	bipolar affective - now manic \| bipolar affective disorder, currently manic
E1140	manic bipolar affective- unspec \| bipolar affective disorder, currently manic, unspecified
E1141	manic bipolar affective- mild \| bipolar affective disorder, currently manic, mild
E1142	manic bipolar affect.- moderate \| bipolar affective disorder, currently manic, moderate
E1143	manic bipolar affect.- severe \| bipolar affective disorder, currently manic, severe, no psychosis \| bipolar affective disorder, currently manic, severe, without mention of psychosis
E1144	manic bipol.affect.severe +psyc \| bipolar affective disord, currently manic, severe with psychosis \| bipolar affective disorder, currently manic, severe, with psychosis
E1145	manic bipol.affect.part remiss \| bipolar affective disord, currently manic, part/unspec remission \| bipolar affective disorder, currently manic, in partial or unspecified remission
E1146	manic bipol.affect.full remiss \| bipolar affective disord, full remission \| bipolar affective disorder, currently manic, in fullremission
E114z	manic bipolar affective nos\| bipolar affective disorder, currently manic, nos
E115.	bipolar affective - now depres \| bipolar affective disorder, currently depressed
E1150	depressed bipolar affect.-unsp \| bipolar affective disorder, currently depressed, unspecified
E1151	depress. bipolar affect.-mild \| bipolar affective disorder, currently depressed, mild
E1152	depr.bipolar affect.-moderate \| bipolar affective disorder, currently depressed, moderate
E1153	depr.bipolar affect.-severe \| bipolar affective disorder, now depressed, severe, no psychosis \| bipolar affective disorder, currently depressed, severe without mention of psychosis
E1154	depr.bipolar affect.-severe +psyc \| bipolar affective disorder, now depressed, severe withpsychosis \| bipolar affective disorder, currently depressed, severe with psychosis
E1155	depr.bipolar affect.-part remiss \| bipolar affective disorder, now depressed, part/unspec remission\| bipolar affective disorder, currently depressed, in partial or unspecified remission
E1156	depr.bipolar affect.-full remiss \| bipolar affective disorder, now depressed, in full remission\| bipolar affective disorder, currently depressed, in full remission
E115z	depressed bopolar affect. nos \| bipolar effective disorder, currently depressed, nos
E116.	mixed bipolar affective disord \| mixed bipolar affective disorder
E1160	mixed bipolar affective- unspec \| mixed bipolar affective disorder, unspecified
E1161	mixed bipolar affective- mild \| mixed bipolar affective disorder, mild
E1162	mixed bipolar affective- moderate \| mixed bipolar affective disorder, moderate
E1163	mixed bipolar affective- severe \| mixed bipolar affective disorder, severe, without mention of psychosis
E1164	mixed bipol.affect. severe+psyc\| mixed bipolar affective disorder, severe, with psychosis
E1165	mixed bipol.affect.part remiss\| mixed bipolar affective disorder, partial/unspec remission \| mixed bipolar affective disorder, in partial or unspecified remission
E1166	mixed bipol.affect.fullremiss\| mixed bipolar affective disorder, in full remission
E116z	mixed bipolar affective nos \| mixed bipolar affective disorder, nos
E117.	unspec bipolar affect disord \| unspecified bipolar affective disorder
E1170	unspecified bipolar affective \| unspecified bipolar affective disorder, unspecified
E1171	unsp.bipolar affective- mild \| unspecified bipolar affective disorder, mild
E1172	unsp.bipolar affective- moderate \| unspecified bipolar affective disorder, moderate
E1173	unsp.bipolar affective- severe \| unspecified bipolar affective disorder, severe, no psychosis \| unspecified bipolar affective disorder, severe, without mention of psychosis
E1174	unsp.bipolar affective- severe +psyc \| unspecified bipolar affective disorder, severe with psychosis \| unspecified bipolar affective disorder, severe, with psychosis
E1175	unsp.bipolar affective- part remiss \| unspecified bipolar affective disorder, partial/unspec remission \| unspecified bipolar affective disorder, in partial or unspecified remission
E1176	unsp.bipolar affective- full remiss \| unspecified bipolar affective disorder, in full remission
E117z	unspecif.bipolar affective- nos \| unspecified bipolar affective disorder, nos
E11y.	other manic-depressive psychos \| other and unspecified manic- depressive psychoses
E11y0	unspec manic-depressive psychos \| unspecified manic- depressive psychoses
E11y1	atypical manic disorder
E11y2	atypical depressive disorder
E11y3	other mixed manic-depress psych \| other mixed manic-depressive osychoses
E11yz	other manic-depress.psych.nos \| other unspecified manic-depressive psychoses nos
Eu30.	[x] manic episide
Eu300	[x] hypomania
Eu301	[x] manic without psychotic sym\| [x] mania without psychotic symptoms
Eu302	[x] mania with psychotic sympts \| [x] mania with psychotic symptoms
Eu30y	[x] other manic episodes
Eu30z	[x] manic episode, unspecified
Eu31.	[x] bipolar affective disorder
Eu310	[x] bipol affec current hypoman \| [x]bipolar affective disorder, current episode hypomanic
Eu311	[x] bipol aff, manic no psychos \| [x]bipolar effective disorder cur epi manic wout psychotic symp\| [x] bipolar affective disorder, current episode manic without psychotic symptoms
Eu312	[x] bipol affect, manic +psychos \| [x]bipolar effective disorder cur epi manic with psychotic symp\| [x] bipolar affective disorder, current episode manic with psychotic symptoms
Eu313	[x] bipol aff, mild/mod depress\| [x]bipolar effective disorder cur epi mild or moderate depressn\| [x] bipolar affective disorder, current episode mild or moderate depression
Eu314	[x] bipol ad, cur sev dep, no psy\| [x]bipol aff disord, curr epis sev depress, no psychot symp\| [x] bipolar affective disorder, current episode severe depression without psychotic symptoms
Eu315	[x] bipol aff sev depress/psych\| [x]bipolar affect dis cur epi severe depres with psyc symp\| [x] bipolar affective disorder, current episode severe depression with psychotic symptoms
Eu316	[x] bipol affect dis, mixed \| [x] bipolar affective disorder, current episode mixed
Eu317	[x] bipol affect dis remission \| [x] bipolar affective disorder, currently in remission
Eu318	[x] bipol affect disord type i\| [x] bipolar affective disorder type i
Eu319	[x] bipol affect disord type ii\| [x] bipolar affective disorder type ii
Eu31y	[x] oth bipolar affect disord \| [x] other bipolar affective disorders
Eu31z	[x] bipolar affect dis unsp \| [x] bipolar affective disorders, unspecified

C2715/6846 Other Psychotic Disorders - Primary Care - Read codes v2

Rows: 34

Code	Description
146H.	h/o: psychosis
8HHs.	ref psychosis early inter ser \| referral to psychosis early intervention service
9H8..	on severe mental ullness regist \| on severe mental illness register
E11..	affective psychoses
E1124	single maj. Depress,severe+psyc \| single major depressive episode, severe, with psychosis
E1134	recurr.maj.depress.-severe+psyc \| recurrent major depressive episodes, severe, with psychosis
E11z.	other/unsp.affective psychoses \| other and unspecified affective psychoses
E11z0	unspecif.affective psych.nos \| unspecified affective psychoses nos
E11zz	other affective psychosis nos
E13..	other nonorganix psychoses
E130.	reactive depressive psychosis
E131.	acute hysterical psychosis
E132.	reactive confusion
E133.	acute paranoid reaction
E134.	psychogenic paranoid psychosis
E13y.	other reactive psychoses
E13y0	psychogenic stupor
E13y1	brief reactive psychoses nos
E13yz	other reactive psychoses nos
E13z.	nonorganic psychoses nos
E1y..	non-organic psychoses os \| other specified non-organic psychoses
E1z..	non-organic psychosis nos
Eu23.	[x] acute/transient psychot dis \| [x]acute and transient psychotoc disorders
Eu230	[x] ac polymorph psych, no schiz \| [x]acute polymorphoc psychot disord without symp of schizoph \| [x]acute polymorphic psychotic disorder without symptoms of schizophrenia
Eu231	[x] ac polymorph psych +schiz \| [x]acute polymorphoc psychot disord with symp of schizoph \| [x]acute polymorphic psychotic disorder with symptoms of schizophrenia
Eu232	[x] ac schizoph-like psych dis \| [x] acute schizophrenia-like psychotic disorder
Eu233	[x] oth ac predom delus psy dis \| [x] other acute predominantly delusional psychotic disorders
Eu23y	[x] oth ac and trans psych dis \| [x] acute and transient psychotic disorders
Eu23z	[x] ac and trand psych dis unsp \| [x] acute and transient psychotic disorder, unspecified
Eu323	[x] severe depressive + psychot \| [x] severe depressive episode with psychotic symptoms
Eu328	[x] maj dep, sev with psychot symp\| [x]major depression, severe with psychotic symptoms
Eu329	[x] sin ma dep ef sev ps ps rem \| [x] single major depre ep, severe with psych, psych in remiss \| [x] single major depressive episode, severe with psychosis, psychosis in remission
Eu32A	[x] rec ma dep ef sev ps ps rem \| [x] recurr major depre ep, severe with psych, psych in remiss \| [x] recurrent major depressive episode, severe, with psychosis, psychosis in remission
Eu333	[x] recurr dep now sever+psych \| [x] recurrent depress disorder cur epi severe with psyc symp \| [x] recurrent depressive disorder, current episode severe with psychotic symptoms

C2716/6848 Schizophrenia - Primary Care - Read codes v2

Rows: 97

Code	Description
1464.	h/o: schizophrenia
E10..	schizophrenic disorders
E100.	simple schizophrenia
E1000	schizophrenia - unspecified \| unspecified schizophrenia
E1001	schizophrenia- subchronic \|subchronic schizophrenia
E1002	schizophrenia- chronic type \| chronic schizophrenic
E1003	schizophrenia- subchr.+acute ex \| acute exacerbation of subchronic schizophrenia
E1004	schizophrenia- chr.+acute exac.\| acute exacerbation of chronic schizophrenia
E1005	schizophrenia in remission
E100z	simple schizophrenia nos
E101.	hebephrenic schizophrenia
E1010	hebephrenia - unspecified \| unspecified hebephrenic schizophrenia
E1011	hebephrenia - subchronic \| subchronic hebephrenic schizophrenia
E1012	hebephrenia - chronic \| chronic hebephrenic schizophrenia
E1013	hebephrenia - subchr.+acute exac\| acute exacerbation of subchronic hebephrenic schizophrenia
E1014	hebephrenia - chronic+acute exac \| acute exacerbation of chronic hebephrenic schizophrenia
E1015	hebephrenia - in remission \| hebephrenic schizophrenia in remission
E101z	hebephrenic schizophrenia nos
E102.	catatonic schizophrenia
E1020	catetonia - unspecified \| unspecified catatonic schizophrenia
E1021	catetonia - subchronic \| subchronic catatonic schizophrenia
E1022	catetonia - chronic \| chronic catatonic schizophrenia
E1023	catetonia - subchr.+acute exac.\| acute exacerbation of subchronic catatonic schizophrenia
E1024	catetonia - chronic.+acute exacer.\| acute exacerbation of chronic catatonic schizophrenia
E1025	catetonia - in remission\| catatonic schizophrenia in remission
E102z	catetonic schizophrenia nos
E103.	paranoid schizophrenia
E1030	paranoid schizo., unspecified \| unspecified paranoid schizophrenia
E1031	paranoid schizo., subchronic \| subchronic paranoid schizophrenia
E1032	paranoid schizo., chronic \| chronic paranoid schizophrenia
E1033	paranoid schizo., -subchr.+ac ex\| acute exacerbation of subchronic paranoid schizophrenia
E1034	paranoid schizo., -chr.+acute ex\| acute exacerbation of chronic paranoid schizophrenia
E1035	paranoid schizo., -in remission\| paranoid schizophrenia in remission
E103z	paranoid schizophrenia nos
E104.	acute schizophrenic episode
E105.	latent schizophrenia
E1050	latent schizo.- unspecified \| unspecified latent schizophrenia
E1051	latent schizo.- subchronic \| subchronic latent schizophrenia
E1052	latent schizo.- chronic \| chronic latent schizophrenia
E1053	latent schizo.- subchr.+ac.exac\| acute exacerbation of subchronic latent schizophrenia
E1054	latent schizo.- chr.+acute exac \| acute exacerbation of chronic latent schizophrenia
E1055	latent schizo.- in remission \| latent schizophrenia in remission
E105z	latent schizophrenia nos
E106.	residual schizophrenia
E107.	schizo-affective schizophrenia
E1070	schizo-affective- unspecified \| unspecified schizo-affective schizophrenia
E1071	schizo-affective- subchronic \| subchronic schizo-affective schizophrenia
E1072	schizo-affective- chronic \| chronic schizo-affective schizophrenia
E1073	schizo-affective- subchr.+ac ex \| acute exacerbation of subchronic schizo-affective schizophrenia
E1074	schizo-affective- chr.+acute ex \| acute exacerbation of chronic schizo-affective schizophrenia
E1075	schizo-affective- in remission\| schizo-affective schizophrenia in remission
E107z	schizo-affective- schizophr.nos\| schizo-affective schizophrenia nos
E10y.	other schizophrenia
E10y0	atypical schizophrenia
E10y1	coenesthopathic schizophrenia
E10yz	other schizophrenia nos
E10z.	schizophrenia nos
E12..	paranoid states
E120.	simple paranoid state
E121.	chronic paranoid psychosis
E122.	paraphrenia
E123.	shared paranoid disorder
E12y.	other paranoid states
E12y0	paranoia querulans
E12yz	other paranoid states nos
E12z.	paranoid psychosis nos
E2122	schizotypal personality
Eu2..	[x]schizoph, schizotyp, delusion \| [x]schizophrenia, schizotypal and delusional disorders
Eu20.	[x]schizophrenia
Eu200	[x]paranoid schizophrenia
Eu201	[x] hebephrenic schizophrenia
Eu202	[x] catatonic schizophrenia
Eu203	[x] undifferentiated schizophrn \| [x]undifferentiated schizophrenia
Eu204	[x] post-schizophrenic depressn \| [x] post-schizophrenic depression
Eu205	[x] residential schizophrenia
Eu206	[x] simple schizophrenia
Eu20y	[x] other schizophrenia
Eu20z	[x] schizophrenia, unspecified
Eu21.	[x] schizotypal disorder
Eu22.	[x] persistent delusional dis \| [x]persistent delusional disorders
Eu220	[x] delusional disorder
Eu221	[x] delision misidentificat syn \| [x] delusional misidentification syndrome
Eu222	[x] cotard syndrome
Eu223	[x] paranoid state in remission
Eu22y	[x] oth persistent delusion dis \| [x] other oersistent delusional disorders
Eu22z	[x] persist delusion dis, unsp \| [x]persistent delusional disorder, unspecified
Eu24.	[x] induced delusional disorder \| [x] induced delusional disorder
Eu25.	[x] schizoaffective disorders
Eu250	[x] schizaffect dis manic type \| [x]schizoaffective disorder, manic type
Eu251	[x] schizaffect dis depres type \| [x]schizoaffective disorder, depressive type
Eu252	[x] schizaffect dis mixed type \| [x]schizoaffective disorder, mixed type
Eu25y	[x] ot schizaffective disorder \| [x]other schizoaffective disorder
Eu25z	[x] schizaffective disord unsp\| [x]schizoaffective disorder, unspecified
Eu26.	[x] nonorgan psychos in remiss\| [x]nonorganic psychosis in remission
Eu2y.	[x] ot nonorgan psychotic dis\| [x]other nonorganic psychotic disorders
Eu2z.	[x] ot nonorgan psychotic dis\| [x]other nonorganic psychotic disorders
ZV110	[v]ph - schizophrenia \| [v]personal history of schizophrenia

API

To Export Phenotype Details:

Format	API
XML	site_root/api/v1/public/phenotypes/PH940/version/1959/detail/?format=xml
JSON	site_root/api/v1/public/phenotypes/PH940/version/1959/detail/?format=json
R Package	`# Download here library(ConceptLibraryClient) # Connect to API client = connect_to_API(public=TRUE) # Get details of phenotype details = get_phenotype_detail_by_version('PH940', '1959', api_client=client)`

To Export Phenotype Code List:

Format	API
XML	site_root/api/v1/public/phenotypes/PH940/version/1959/export/codes/?format=xml
JSON	site_root/api/v1/public/phenotypes/PH940/version/1959/export/codes/?format=json
CSV	site_root/phenotypes/PH940/version/1959/export/codes/
R Package	`# Download here library(ConceptLibraryClient) # Connect to API client = connect_to_API(public=TRUE) # Get codelists of phenotype codelists = get_phenotype_code_list('PH940', '1959', api_client=client)`

Version History

Version ID	Name	Owner	Publish date
1959	Bipolar Disorder, Schizophrenia and Other Psychotic Disorders Primary Care	ieuan.scanlon	2022-05-05	currently shown